迪斯科热：阿根廷东北部与光顾迪斯科舞厅相关的流行性脑膜炎球菌病

Disco fever: epidemic meningococcal disease in northeastern Argentina associated with disco patronage.

作者信息

Cookson S T, Corrales J L, Lotero J O, Regueira M, Binsztein N, Reeves M W, Ajello G, Jarvis W R

机构信息

Hospital Infections Program, Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

出版信息

J Infect Dis. 1998 Jul;178(1):266-9. doi: 10.1086/517450.

DOI:10.1086/517450

PMID:9652452

Abstract

Neisseria meningitidis is a leading cause of adult meningitis worldwide. From 5 to 14 August 1996, 8 cases of meningococcal disease occurred in Corrientes city (population 306,000) in northeastern Argentina. Those infected ranged in age from 15 to 45 years (median, 18.5). To determine risk factors for infection, a case-control study was done. Infecting isolates were serogrouped and underwent phenotyping by multilocus enzyme electrophoresis (MLEE) and pulsed-field gel electrophoresis (PFGE). Those infected were significantly more likely than those not infected to have had exposure to passive or active cigarette smoke or to have attended a particular disco. Isolates available from 6 case-patients were all serogroup C; all had identical MLEE and PFGE patterns. These data suggest that dance clubs or discos may be a focus of transmission of N. meningitidis among young people.

摘要

脑膜炎奈瑟菌是全球成人脑膜炎的主要病因。1996年8月5日至14日，阿根廷东北部科连特斯市（人口30.6万）发生了8例脑膜炎球菌病病例。感染者年龄在15至45岁之间（中位数为18.5岁）。为确定感染的危险因素，开展了一项病例对照研究。对感染分离株进行血清分组，并通过多位点酶电泳（MLEE）和脉冲场凝胶电泳（PFGE）进行表型分析。与未感染者相比，感染者接触被动或主动吸烟或去过某一特定迪斯科舞厅的可能性显著更高。从6例病例患者获得的分离株均为C血清群；所有分离株的MLEE和PFGE模式均相同。这些数据表明，舞蹈俱乐部或迪斯科舞厅可能是脑膜炎奈瑟菌在年轻人中传播的一个聚集场所。