某大学社区脑膜炎球菌病暴发的分子流行病学
Molecular epidemiology of an outbreak of meningococcal disease in a university community.
作者信息
Edmond M B, Hollis R J, Houston A K, Wenzel R P
机构信息
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA.
出版信息
J Clin Microbiol. 1995 Aug;33(8):2209-11. doi: 10.1128/jcm.33.8.2209-2211.1995.
Abstract
Over a 2-month period, five cases of serogroup C meningococcal disease occurred in Iowa City, Iowa. Two patients were unacquainted university students who had independently visited another university with endemic meningococcal disease. Isolates from these patients had DNA fingerprints identical to those of the isolates responsible for infections on the other campus. Three cases for which the patients' isolates had a different DNA fingerprint were linked to visiting a local tavern. To disrupt the outbreak, the University of Iowa offered free meningococcal vaccine to all students. This report demonstrates that outbreaks of meningococcal disease may be due to more than one circulating strain and illustrates the utility of pulsed-field gel electrophoresis in defining the molecular epidemiology of meningococcal infections.
摘要
在为期2个月的时间里，爱荷华州爱荷华城出现了5例C群脑膜炎球菌病病例。两名患者是互不相识的大学生，他们各自前往另一所存在地方性脑膜炎球菌病的大学。从这些患者身上分离出的菌株，其DNA指纹与另一所校园感染源的菌株相同。另外3例患者的菌株具有不同的DNA指纹，这些病例与前往当地一家酒馆有关。为了控制疫情，爱荷华大学为所有学生提供免费的脑膜炎球菌疫苗。本报告表明，脑膜炎球菌病的暴发可能由不止一种流行菌株引起，并说明了脉冲场凝胶电泳在确定脑膜炎球菌感染分子流行病学方面的作用。
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