细菌中五肽重复序列的结构与分布
Structure and distribution of pentapeptide repeats in bacteria.
作者信息
Bateman A, Murzin A G, Teichmann S A
机构信息
Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
出版信息
Protein Sci. 1998 Jun;7(6):1477-80. doi: 10.1002/pro.5560070625.
Abstract
We report the discovery of a novel family of proteins, each member contains tandem pentapeptide (five residue) repeats, described by the motif A(D/N)LXX. Members of this family are both membrane bound and cytoplasmic. The function of these repeats is uncertain, but they may have a targeting or structural function rather than enzymatic activity. This family is most common in cyanobacteria, suggesting a function related to cyanobacterial-specific metabolism. Although no experimental information is available for the structure of this family, it is predicted that the tandem pentapeptide repeats will form a right-handed beta-helical structure. A structural model of the pentapeptide repeats is presented.
摘要
我们报告了一个新的蛋白质家族的发现，该家族的每个成员都包含串联五肽（五个残基）重复序列，其基序为A(D/N)LXX。这个家族的成员既有膜结合的，也有胞质的。这些重复序列的功能尚不确定，但它们可能具有靶向或结构功能，而非酶活性。这个家族在蓝细菌中最为常见，这表明其功能与蓝细菌特有的代谢有关。尽管目前尚无关于该家族结构的实验信息，但据预测，串联五肽重复序列将形成右手β-螺旋结构。本文给出了五肽重复序列的结构模型。
相似文献
1
Structure and distribution of pentapeptide repeats in bacteria.细菌中五肽重复序列的结构与分布
Protein Sci. 1998 Jun;7(6):1477-80. doi: 10.1002/pro.5560070625.
2
Insights into the structural variation between pentapeptide repeat proteins--crystal structure of Rfr23 from Cyanothece 51142.对五肽重复蛋白结构变异的见解——蓝细菌51142中Rfr23的晶体结构
J Struct Biol. 2008 Apr;162(1):184-92. doi: 10.1016/j.jsb.2007.11.008. Epub 2007 Nov 28.
3
Structural dynamics of pentapeptide repeat proteins.五肽重复蛋白的结构动力学。
Proteins. 2020 Nov;88(11):1493-1512. doi: 10.1002/prot.25969. Epub 2020 Jul 11.
4
Cloning, expression, crystallization and preliminary crystallographic analysis of a pentapeptide-repeat protein (Rfr23) from the bacterium Cyanothece 51142.蓝细菌Cyanothece 51142中一种五肽重复蛋白（Rfr23）的克隆、表达、结晶及初步晶体学分析
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt 12):1251-4. doi: 10.1107/S174430910604663X. Epub 2006 Nov 30.
5
Pentapeptide repeat proteins.五肽重复蛋白
Biochemistry. 2006 Jan 10;45(1):1-10. doi: 10.1021/bi052130w.
6
Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein.来自点状念珠藻的两种五肽重复蛋白Np275和Np276融合体的结构表征：一种祖先蛋白的复活
Protein Sci. 2007 Apr;16(4):755-60. doi: 10.1110/ps.062637707.
7
Current Understanding of the Structure and Function of Pentapeptide Repeat Proteins.目前对五肽重复蛋白结构和功能的认识。
Biomolecules. 2021 Apr 26;11(5):638. doi: 10.3390/biom11050638.
8
Filamentous hemagglutinin of Bordetella pertussis. A bacterial adhesin formed as a 50-nm monomeric rigid rod based on a 19-residue repeat motif rich in beta strands and turns.百日咳博德特氏菌的丝状血凝素。一种细菌粘附素，基于富含β链和转角的19个残基重复基序形成50纳米的单体刚性杆。
J Mol Biol. 1994 Aug 5;241(1):110-24. doi: 10.1006/jmbi.1994.1478.
9
Characterization of two potentially universal turn motifs that shape the repeated five-residues fold--crystal structure of a lumenal pentapeptide repeat protein from Cyanothece 51142.塑造重复五残基折叠的两种潜在通用转角基序的表征——来自蓝细菌51142的腔内五肽重复蛋白的晶体结构
Protein Sci. 2006 Nov;15(11):2579-95. doi: 10.1110/ps.062407506.
10
Conformational analysis of pentapeptide sequences matching a proposed recognition motif for lysosomal degradation.与溶酶体降解的一个拟议识别基序相匹配的五肽序列的构象分析。
Biochim Biophys Acta. 1996 Apr 16;1293(2):243-53. doi: 10.1016/0167-4838(95)00256-1.
引用本文的文献
1
Secretins of type-two secretion systems are necessary for exopolymeric slime secretion in cyanobacteria and myxobacteria.
Nat Commun. 2025 Sep 26;16(1):8482. doi: 10.1038/s41467-025-63426-x.
2
Exploring proteins within the coccolith matrix.探索颗石藻基质中的蛋白质。
Sci Rep. 2024 Dec 30;14(1):31821. doi: 10.1038/s41598-024-83052-9.
3
Complete Reconstitution of the Apramycin Biosynthetic Pathway Demonstrates the Unusual Incorporation of a β-d-Sugar Nucleotide in the Final Glycosylation Step.阿帕霉素生物合成途径的完全重建表明在最后糖基化步骤中β-d-糖核苷酸的不寻常掺入。
J Am Chem Soc. 2024 Apr 10;146(14):10103-10114. doi: 10.1021/jacs.4c01233. Epub 2024 Mar 28.
4
A structural biology community assessment of AlphaFold2 applications.AlphaFold2 应用的结构生物学社区评估。
Nat Struct Mol Biol. 2022 Nov;29(11):1056-1067. doi: 10.1038/s41594-022-00849-w. Epub 2022 Nov 7.
5
Long-Read Metagenomics Improves the Recovery of Viral Diversity from Complex Natural Marine Samples.长读宏基因组提高了从复杂自然海洋样本中病毒多样性的恢复。
mSystems. 2022 Jun 28;7(3):e0019222. doi: 10.1128/msystems.00192-22. Epub 2022 Jun 13.
6
T6SS Accessory Proteins, Including DUF2169 Domain-Containing Protein and Pentapeptide Repeats Protein, Contribute to Bacterial Virulence in T6SS Group_5 of BGR1.VI型分泌系统（T6SS）辅助蛋白，包括含DUF2169结构域的蛋白和五肽重复序列蛋白，对BGR1的T6SS第5组中的细菌毒力有贡献。
Plants (Basel). 2021 Dec 23;11(1):34. doi: 10.3390/plants11010034.
7
Bacterial death and TRADD-N domains help define novel apoptosis and immunity mechanisms shared by prokaryotes and metazoans.细菌死亡和 TRADD-N 结构域有助于定义原核生物和后生动物共有的新的细胞凋亡和免疫机制。
Elife. 2021 Jun 1;10:e70394. doi: 10.7554/eLife.70394.
8
Current Understanding of the Structure and Function of Pentapeptide Repeat Proteins.目前对五肽重复蛋白结构和功能的认识。
Biomolecules. 2021 Apr 26;11(5):638. doi: 10.3390/biom11050638.
9
Pentapeptide repeat protein QnrB1 requires ATP hydrolysis to rejuvenate poisoned gyrase complexes.五肽重复蛋白 QnrB1 需要 ATP 水解来使被毒化的拓扑异构酶复合物恢复活力。
Nucleic Acids Res. 2021 Feb 22;49(3):1581-1596. doi: 10.1093/nar/gkaa1266.
10
The complex genetic region conferring transferable antibiotic resistance in multidrug-resistant and extremely drug-resistant clinical isolates.在多重耐药和广泛耐药临床分离株中赋予可转移抗生素耐药性的复杂基因区域。
New Microbes New Infect. 2020 May 14;36:100693. doi: 10.1016/j.nmni.2020.100693. eCollection 2020 Jul.
本文引用的文献
1
Leucines on a roll.亮氨酸发挥作用。
Nat Struct Biol. 1996 Dec;3(12):977-80. doi: 10.1038/nsb1296-977.
2
Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions.单细胞蓝藻聚球藻属PCC6803菌株基因组的序列分析。II. 全基因组序列测定及潜在蛋白质编码区的归属
DNA Res. 1996 Jun 30;3(3):109-36. doi: 10.1093/dnares/3.3.109.
3
Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.与53BP2的锚蛋白和SH3结构域结合的p53肿瘤抑制因子的结构
Science. 1996 Nov 8;274(5289):1001-5. doi: 10.1126/science.274.5289.1001.
4
Hidden Markov models.隐马尔可夫模型
Curr Opin Struct Biol. 1996 Jun;6(3):361-5. doi: 10.1016/s0959-440x(96)80056-x.
5
Structure of Bordetella pertussis virulence factor P.69 pertactin.百日咳博德特氏菌毒力因子69kDa外膜蛋白的结构
Nature. 1996 May 2;381(6577):90-2. doi: 10.1038/381090a0.
6
New domain motif: the structure of pectate lyase C, a secreted plant virulence factor.新的结构域基序：果胶酸裂解酶C的结构，一种分泌型植物致病因子。
Science. 1993 Jun 4;260(5113):1503-7. doi: 10.1126/science.8502994.
7
Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes.大肠杆菌基因组分析。IV. 89.2至92.8分钟区域的DNA序列。
Nucleic Acids Res. 1993 Nov 25;21(23):5408-17. doi: 10.1093/nar/21.23.5408.
8
Comparative protein modelling by satisfaction of spatial restraints.通过空间约束满足进行比较蛋白质建模。
J Mol Biol. 1993 Dec 5;234(3):779-815. doi: 10.1006/jmbi.1993.1626.
9
The hglK gene is required for localization of heterocyst-specific glycolipids in the cyanobacterium Anabaena sp. strain PCC 7120.hglK基因是蓝藻鱼腥藻PCC 7120株异形胞特异性糖脂定位所必需的。
J Bacteriol. 1995 Nov;177(22):6440-8. doi: 10.1128/jb.177.22.6440-6448.1995.
10
Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin.对枯草芽孢杆菌染色体中包含复制起点的180千碱基区域进行系统测序。
DNA Res. 1994;1(1):1-14. doi: 10.1093/dnares/1.1.1.
Zotero 插件