鼠白血病病毒Gag多聚蛋白与KIF4（一种基于微管的驱动蛋白）的结合。
Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.
作者信息
Kim W, Tang Y, Okada Y, Torrey T A, Chattopadhyay S K, Pfleiderer M, Falkner F G, Dorner F, Choi W, Hirokawa N, Morse H C
机构信息
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
出版信息
J Virol. 1998 Aug;72(8):6898-901. doi: 10.1128/JVI.72.8.6898-6901.1998.
Abstract
A cDNA clone encoding a cellular protein that interacts with murine leukemia virus (MuLV) Gag proteins was isolated from a T-cell lymphoma library. The sequence of the clone is identical to the C terminus of a cellular protein, KIF4, a microtubule-associated motor protein that belongs to the kinesin superfamily. KIF4-MuLV Gag associations have been detected in vitro and in vivo in mammalian cells. We suggest that KIF4 could be involved in Gag polyprotein translocation from the cytoplasm to the cell membrane.
摘要
从一个T细胞淋巴瘤文库中分离出一个编码与鼠白血病病毒（MuLV）Gag蛋白相互作用的细胞蛋白的cDNA克隆。该克隆的序列与一种细胞蛋白KIF4的C末端相同，KIF4是一种微管相关运动蛋白，属于驱动蛋白超家族。在哺乳动物细胞的体外和体内均检测到KIF4与MuLV Gag的结合。我们认为KIF4可能参与Gag多蛋白从细胞质到细胞膜的转运。
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