Faddy M J, Jones E C, Edwards R G
J Exp Zool. 1976 Aug;197(2):173-85. doi: 10.1002/jez.1401970203.
Differential counts of follicles of different sizes in the ovaries of intact and hypophysectomized strain A mice of various ages have been analysed statistically. The influence of age on the number of follicles in each size group is described. The number of small follicles in the ovarian pool declined exponentially, whereas numbers of follicles in other groups displayed two peaks, one during immaturity and the other in adult life. These appeared sequentially in follicles in successive groups. The proportion of follicles growing and dying was estimated and age dependent fluctuations in the time spent by follicles in each group were demonstrated. Further calculations then determined the mean inflow and outflow of follicles to and from the various groups throughout the lifespan. Hypophysectomy during post-puberty decreased only slightly the utilization of small follicles from the pool and did not prevent their subsequent development to the two-layered stage. Many follicles then died at this stage of development, indicating that the initial main site of gonadotrophic action may be on medium sized follicles with two layers of granulosa cells.
对不同年龄的完整和垂体切除的A品系小鼠卵巢中不同大小卵泡的差异计数进行了统计分析。描述了年龄对每个大小组卵泡数量的影响。卵巢池中小卵泡的数量呈指数下降，而其他组卵泡数量出现两个峰值，一个在未成熟阶段，另一个在成年期。这些峰值在连续组的卵泡中依次出现。估计了生长和死亡卵泡的比例，并证明了卵泡在每组中停留时间的年龄依赖性波动。进一步的计算确定了整个生命周期中卵泡进出各个组的平均流入和流出情况。青春期后进行垂体切除仅略微降低了卵巢池中小卵泡的利用率，并且没有阻止它们随后发育到两层阶段。然后许多卵泡在这个发育阶段死亡，这表明促性腺激素作用的初始主要部位可能是在具有两层颗粒细胞的中等大小卵泡上。
