An analytical model for ovarian follicle dynamics.

Differential counts of follicles of different sizes in the ovaries of intact and hypophysectomized strain A mice of various ages have been analysed statistically. The influence of age on the number of follicles in each size group is described. The number of small follicles in the ovarian pool declined exponentially, whereas numbers of follicles in other groups displayed two peaks, one during immaturity and the other in adult life. These appeared sequentially in follicles in successive groups. The proportion of follicles growing and dying was estimated and age dependent fluctuations in the time spent by follicles in each group were demonstrated. Further calculations then determined the mean inflow and outflow of follicles to and from the various groups throughout the lifespan. Hypophysectomy during post-puberty decreased only slightly the utilization of small follicles from the pool and did not prevent their subsequent development to the two-layered stage. Many follicles then died at this stage of development, indicating that the initial main site of gonadotrophic action may be on medium sized follicles with two layers of granulosa cells.