Carter R, al-Rawas O A, Stevenson R D, Naik S K, Wheatley D J
Department of Respiratory Medicine, Glasgow Royal Infirmary, U.K.
Respir Med. 1998 Apr;92(4):628-32. doi: 10.1016/s0954-6111(98)90508-x.
In contrast to the standard single-breath transfer factor for carbon monoxide (TLCO), there are no specific guidelines or recommendations for the measurement of its components, the pulmonary capillary blood volume (VC) and membrane component (DM), by the Roughton and Forster method. Ten randomly selected heart transplant patients (three life-long non-smokers, seven ex-smokers > 1 yr, age range 24-55 years) were assessed on two occasions using either the standard or high-oxygen mixture as the first inspired gas in random order. Ten normal subjects (all non-smokers, age range 23-54 years) were assessed on two occasions using either a long protocol (30 min waiting time between repeat measurements in an individual set) or a short protocol (5 min waiting time). Two technically acceptable results of TLCO were used to derive a mean value for DM and VC for each set of measurements (Transflow, P. K. Morgan, Kent, U.K.). The different sequences of gas mixtures produced no significant differences between the values obtained in ten heart transplant patients for mean TLCO (mmol min-1 kPa-1) (standard first 5.13 +/- 1.15, high-oxygen first 5.14 +/- 1.12; limits of agreement -0.57 to 0.59 for DM or for VC. The long or short protocol produced no significant differences between the means of TLCO (mmol min-1 kPa-1) (long 8.0 +/- 1.9, short 8.0 +/- 1.9; limits of agreement -0.5 to 0.5), DM or VC. This allows the development of a standard test protocol of short duration (about 40 min) making it practical for clinical use without compromising the precision or reproducibility of the results obtained.
与标准的一氧化碳单次呼吸转移因子（TLCO）不同，对于通过罗顿和福斯特方法测量其组成部分——肺毛细血管血容量（VC）和膜成分（DM），没有具体的指南或建议。随机选择了10名心脏移植患者（3名终生不吸烟者，7名戒烟超过1年者，年龄范围24 - 55岁），以随机顺序分两次使用标准或高氧混合气作为首次吸入气体进行评估。10名正常受试者（均为不吸烟者，年龄范围23 - 54岁）分两次使用长方案（个体组内重复测量之间等待30分钟）或短方案（等待5分钟）进行评估。每组测量使用两个技术上可接受的TLCO结果来得出DM和VC的平均值（Transflow，P.K.摩根公司，英国肯特）。不同的气体混合顺序在10名心脏移植患者中获得的平均TLCO（mmol min⁻¹ kPa⁻¹）值之间没有显著差异（标准混合气先使用时为5.13 ± 1.15，高氧混合气先使用时为5.14 ± 1.12；DM或VC的一致性界限为 - 0.57至0.59）。长方案或短方案在TLCO（mmol min⁻¹ kPa⁻¹）平均值（长方案8.0 ± 1.9，短方案8.0 ±
