Nazario S, Das S, de Silva A M, Deponte K, Marcantonio N, Anderson J F, Fish D, Fikrig E, Kantor F S
Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
Am J Trop Med Hyg. 1998 Jun;58(6):780-5. doi: 10.4269/ajtmh.1998.58.780.
We examined the effect of repeated infestation of guinea pigs with Ixodes scapularis on the capacity of ticks to transmit Borrelia burgdorferi infection. Repeated challenges with nymphs or larvae lead to a reduction in duration of nymphal tick attachment and weight of recovered ticks consistent with the development of tick immunity. Only one of 18 I. scapularis-immune guinea pigs challenged with B. burgdorferi-infected nymphal ticks became infected, whereas 10 of 18 naive guinea pigs similarly challenged became infected. We conclude that tick immunity interferes with borrelial transmission.
我们研究了用肩突硬蜱反复感染豚鼠对蜱传播伯氏疏螺旋体感染能力的影响。若虫或幼虫的反复攻击导致若虫蜱附着时间缩短以及回收蜱的重量减轻，这与蜱免疫力的发展一致。在用感染伯氏疏螺旋体的若虫蜱攻击的18只具有蜱免疫力的豚鼠中，只有1只被感染，而在同样受到攻击的18只未接触过蜱的豚鼠中，有10只被感染。我们得出结论，蜱免疫力会干扰疏螺旋体的传播。
