红霉素可抑制全血中热灭活肺炎链球菌诱导产生的肿瘤坏死因子α和白细胞介素6。
Erythromycin inhibits tumor necrosis factor alpha and interleukin 6 production induced by heat-killed Streptococcus pneumoniae in whole blood.
作者信息
Schultz M J, Speelman P, Zaat S, van Deventer S J, van der Poll T
机构信息
Department of Infectious Diseases, Tropical Medicine and AIDS, University of Amsterdam, The Netherlands.
出版信息
Antimicrob Agents Chemother. 1998 Jul;42(7):1605-9. doi: 10.1128/AAC.42.7.1605.
Abstract
To determine the effects of penicillin and erythromycin on cytokine production induced by heat-killed Streptococcus pneumoniae (HKSP), we studied the effects of those drugs on cytokine production induced by S. pneumoniae in human whole blood in vitro and ex vivo. In whole blood in vitro, erythromycin, but not penicillin, caused a dose-dependent decrease in HKSP-induced production of tumor necrosis factor alpha (TNF) and interleukin 6 (IL-6), while the production of IL-10, IL-12, and gamma interferon was inhibited only at the highest erythromycin concentration tested (10(-3) M). The production of TNF and IL-6 in whole blood obtained from healthy subjects after a 30-min infusion of erythromycin (1,000 mg) was lower after ex vivo stimulation with HKSP than that in blood drawn before the infusion. Inhibition of TNF contributed to erythromycin-induced inhibition of IL-6 synthesis. Inhibition of TNF and IL-6 production by erythromycin may have a negative impact on host defense mechanisms during pneumococcal pneumonia.
摘要
为了确定青霉素和红霉素对热灭活肺炎链球菌（HKSP）诱导的细胞因子产生的影响，我们在体外和体内研究了这些药物对人全血中肺炎链球菌诱导的细胞因子产生的影响。在体外全血中，红霉素而非青霉素导致HKSP诱导的肿瘤坏死因子α（TNF）和白细胞介素6（IL-6）产生呈剂量依赖性下降，而IL-10、IL-12和γ干扰素的产生仅在测试的最高红霉素浓度（10⁻³ M）下受到抑制。在健康受试者输注红霉素（1000 mg）30分钟后获得的全血中，用HKSP进行体外刺激后，TNF和IL-6的产生低于输注前抽取的血液中的产生。TNF的抑制导致红霉素诱导的IL-6合成抑制。红霉素对TNF和IL-6产生的抑制可能对肺炎球菌肺炎期间的宿主防御机制产生负面影响。
相似文献
1
Erythromycin inhibits tumor necrosis factor alpha and interleukin 6 production induced by heat-killed Streptococcus pneumoniae in whole blood.红霉素可抑制全血中热灭活肺炎链球菌诱导产生的肿瘤坏死因子α和白细胞介素6。
Antimicrob Agents Chemother. 1998 Jul;42(7):1605-9. doi: 10.1128/AAC.42.7.1605.
2
Pharmacokinetic-pharmacodynamic modeling of the inhibitory effect of erythromycin on tumour necrosis factor-alpha and interleukin-6 production.
Fundam Clin Pharmacol. 2001 Dec;15(6):419-24. doi: 10.1046/j.1472-8206.2001.00054.x.
3
Intravenous infusion of erythromycin inhibits CXC chemokine production, but augments neutrophil degranulation in whole blood stimulated with Streptococcus pneumoniae.静脉输注红霉素可抑制CXC趋化因子的产生，但会增强肺炎链球菌刺激的全血中嗜中性粒细胞的脱粒作用。
J Antimicrob Chemother. 2000 Aug;46(2):235-40. doi: 10.1093/jac/46.2.235.
4
Erythromycin inhibits Pseudomonas aeruginosa-induced tumour necrosis factor-alpha production in human whole blood.红霉素可抑制铜绿假单胞菌诱导的人全血中肿瘤坏死因子-α的产生。
J Antimicrob Chemother. 2001 Aug;48(2):275-8. doi: 10.1093/jac/48.2.275.
5
Differential modulation of cytokine production by macrolides: interleukin-6 production is increased by spiramycin and erythromycin.大环内酯类药物对细胞因子产生的差异调节：螺旋霉素和红霉素可增加白细胞介素-6的产生。
Antimicrob Agents Chemother. 1991 Oct;35(10):2016-9. doi: 10.1128/AAC.35.10.2016.
6
Streptococcus pneumoniae strain-dependent lung inflammatory responses in a murine model of pneumococcal pneumonia.肺炎球菌肺炎小鼠模型中肺炎链球菌菌株依赖性的肺部炎症反应
Intensive Care Med. 2003 May;29(5):808-16. doi: 10.1007/s00134-003-1699-x. Epub 2003 Mar 29.
7
Streptococcus pneumoniae autolysis prevents phagocytosis and production of phagocyte-activating cytokines.肺炎链球菌自溶可阻止吞噬作用及吞噬细胞激活细胞因子的产生。
Infect Immun. 2009 Sep;77(9):3826-37. doi: 10.1128/IAI.00290-09. Epub 2009 Jun 15.
8
Heat-killed pneumococci and pneumococcal capsular polysaccharides stimulate tumor necrosis factor-alpha production by murine macrophages.热灭活肺炎球菌和肺炎球菌荚膜多糖可刺激小鼠巨噬细胞产生肿瘤坏死因子-α。
Am J Respir Cell Mol Biol. 1994 Mar;10(3):284-9. doi: 10.1165/ajrcmb.10.3.8117447.
9
Effect of xanthine derivates and dexamethasone on Streptococcus pneumoniae-stimulated production of tumor necrosis factor alpha, interleukin-1 beta (IL-1 beta), and IL-10 by human leukocytes.黄嘌呤衍生物和地塞米松对肺炎链球菌刺激人白细胞产生肿瘤坏死因子α、白细胞介素-1β（IL-1β）和IL-10的影响。
Clin Diagn Lab Immunol. 1995 Nov;2(6):689-92. doi: 10.1128/cdli.2.6.689-692.1995.
10
Essential role for the p40 subunit of interleukin-12 in neutrophil-mediated early host defense against pulmonary infection with Streptococcus pneumoniae: involvement of interferon-gamma.白细胞介素-12的p40亚基在中性粒细胞介导的宿主早期抗肺炎链球菌肺部感染防御中的重要作用：γ干扰素的参与
Microbes Infect. 2004 Nov;6(14):1241-9. doi: 10.1016/j.micinf.2004.08.007.
引用本文的文献
1
Immune Memory After Respiratory Infection With Is Revealed by Stimulation of Murine Splenocytes With Inactivated Pneumococcal Whole Cells: Evidence of Early Recall Responses by Transcriptomic Analysis.呼吸道感染后免疫记忆的揭示：通过用灭活肺炎球菌全细胞刺激小鼠脾细胞：转录组分析证据表明早期回忆反应。
Front Cell Infect Microbiol. 2022 Jun 20;12:869763. doi: 10.3389/fcimb.2022.869763. eCollection 2022.
2
The Anti-Nociceptive Potential of Tulathromycin against Chemically and Thermally Induced Pain in Mice.图拉霉素对化学和热诱导小鼠疼痛的抗伤害感受潜力
Pharmaceutics. 2021 Aug 12;13(8):1247. doi: 10.3390/pharmaceutics13081247.
3
Ex vivo modelling of the formation of inflammatory platelet-leucocyte aggregates and their adhesion on endothelial cells, an early event in sepsis.体外模型研究炎症性血小板-白细胞聚集体的形成及其在内皮细胞上的黏附，这是脓毒症早期的一个事件。
Clin Exp Med. 2019 Aug;19(3):321-337. doi: 10.1007/s10238-018-0526-1. Epub 2018 Sep 6.
4
Macrolide therapy is associated with reduced mortality in acute respiratory distress syndrome (ARDS) patients.大环内酯类药物治疗与急性呼吸窘迫综合征（ARDS）患者死亡率降低相关。
Ann Transl Med. 2018 Jan;6(2):24. doi: 10.21037/atm.2017.12.25.
5
Combination of Erythromycin and Curcumin Alleviates Induced Osteomyelitis in Rats.红霉素和姜黄素联合减轻大鼠诱导性骨髓炎。
Front Cell Infect Microbiol. 2017 Aug 24;7:379. doi: 10.3389/fcimb.2017.00379. eCollection 2017.
6
The Nonantibiotic Macrolide EM703 Improves Survival in a Model of Quinolone-Treated Pseudomonas aeruginosa Airway Infection.非抗生素大环内酯 EM703 改善了喹诺酮类药物治疗的铜绿假单胞菌气道感染模型中的生存率。
Antimicrob Agents Chemother. 2017 Aug 24;61(9). doi: 10.1128/AAC.02761-16. Print 2017 Sep.
7
Exploring the Role of CYP3A4 Mediated Drug Metabolism in the Pharmacological Modulation of Nitric Oxide Production.探索细胞色素P450 3A4介导的药物代谢在一氧化氮产生的药理调节中的作用。
Front Pharmacol. 2017 Apr 12;8:202. doi: 10.3389/fphar.2017.00202. eCollection 2017.
8
On-chip evaluation of neutrophil activation and neutrophil-endothelial cell interaction during neutrophil chemotaxis.在中性粒细胞趋化过程中对中性粒细胞激活和中性粒细胞-内皮细胞相互作用的片上评估。
Anal Chem. 2013 Nov 19;85(22):10787-96. doi: 10.1021/ac4020098. Epub 2013 Oct 28.
9
Mechanisms of action and clinical application of macrolides as immunomodulatory medications.大环内酯类作为免疫调节药物的作用机制和临床应用。
Clin Microbiol Rev. 2010 Jul;23(3):590-615. doi: 10.1128/CMR.00078-09.
10
Immuno-modulation and anti-inflammatory benefits of antibiotics: the example of tilmicosin.抗生素的免疫调节和抗炎益处：替米考星的实例
Can J Vet Res. 2010 Jan;74(1):1-10.
本文引用的文献
1
Epinephrine inhibits endotoxin-induced IL-1 beta production: roles of tumor necrosis factor-alpha and IL-10.肾上腺素抑制内毒素诱导的白细胞介素-1β产生：肿瘤坏死因子-α和白细胞介素-10的作用。
Am J Physiol. 1997 Dec;273(6):R1885-90. doi: 10.1152/ajpregu.1997.273.6.R1885.
2
Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia.白细胞介素-6基因缺陷型小鼠对肺炎球菌肺炎的防御能力受损。
J Infect Dis. 1997 Aug;176(2):439-44. doi: 10.1086/514062.
3
Lipopolysaccharide-induced interleukin 8 production by human whole blood is enhanced by epinephrine and inhibited by hydrocortisone.脂多糖诱导人全血产生白细胞介素8的过程会被肾上腺素增强，被氢化可的松抑制。
Infect Immun. 1997 Jun;65(6):2378-81. doi: 10.1128/iai.65.6.2378-2381.1997.
4
5
Passive immunization against tumor necrosis factor-alpha impairs host defense during pneumococcal pneumonia in mice.被动免疫抗肿瘤坏死因子-α会损害小鼠肺炎球菌肺炎期间的宿主防御功能。
Am J Respir Crit Care Med. 1997 Feb;155(2):603-8. doi: 10.1164/ajrccm.155.2.9032201.
6
Interleukin-10 impairs host defense in murine pneumococcal pneumonia.白细胞介素-10损害小鼠肺炎球菌肺炎中的宿主防御。
J Infect Dis. 1996 Nov;174(5):994-1000. doi: 10.1093/infdis/174.5.994.
7
IL-12 gene therapy protects mice in lethal Klebsiella pneumonia.白细胞介素-12基因疗法可保护小鼠免受致死性肺炎克雷伯菌肺炎的侵害。
J Immunol. 1996 Oct 1;157(7):3006-12.
8
Inhibitory effect of erythromycin on interleukin 8 production by 1 alpha,25-dihydroxyvitamin D3-stimulated THP-1 cells.红霉素对1α,25 - 二羟基维生素D3刺激的THP - 1细胞产生白细胞介素8的抑制作用。
Antimicrob Agents Chemother. 1996 Jun;40(6):1548-51. doi: 10.1128/AAC.40.6.1548.
9
Modulatory effect of antibiotics on cytokine production by human monocytes in vitro.抗生素对人单核细胞体外细胞因子产生的调节作用。
Antimicrob Agents Chemother. 1996 Jun;40(6):1366-70. doi: 10.1128/AAC.40.6.1366.
10
Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia.肾上腺素在人类内毒素血症期间抑制肿瘤坏死因子-α 并增强白细胞介素10的产生。
J Clin Invest. 1996 Feb 1;97(3):713-9. doi: 10.1172/JCI118469.
Zotero 插件