Bailly S, Pocidalo J J, Fay M, Gougerot-Pocidalo M A
Institut National de la Sante et de la Recherche Medicale U.294, Laboratoire d'Immunologie et d'Hematologie Chu X. Bichat, Paris, France.
Antimicrob Agents Chemother. 1991 Oct;35(10):2016-9. doi: 10.1128/AAC.35.10.2016.
Antibiotics do not act alone but act in conjunction with the host defense system. In particular, it has been shown that some antibiotics can modify cytokine production. We compared the in vitro effects of three macrolides (roxithromycin, spiramycin, and erythromycin) actively concentrated by leukocytes on interleukin-1 alpha, (IL-1 alpha), IL-1 beta, IL-6, and tumor necrosis factor alpha production by human monocytes stimulated with lipopolysaccharide. Our results show that the three macrolides tested have different effects on production of these cytokines. Spiramycin and, to a lesser extent, erythromycin increased total IL-6 production without affecting IL-1 alpha, IL-1 beta, or tumor necrosis factor alpha production, whereas roxithromycin had no effect. To our knowledge, this is the first time that an antibiotic has been shown to increase IL-6 production.
抗生素并非单独起作用，而是与宿主防御系统协同发挥作用。特别值得一提的是，已有研究表明某些抗生素能够改变细胞因子的产生。我们比较了三种被白细胞主动摄取的大环内酯类药物（罗红霉素、螺旋霉素和红霉素）对脂多糖刺激的人单核细胞产生白细胞介素-1α（IL-1α）、IL-1β、IL-6和肿瘤坏死因子α的体外影响。我们的研究结果表明，所测试的三种大环内酯类药物对这些细胞因子的产生具有不同的影响。螺旋霉素以及在较小程度上的红霉素可增加IL-6的总产生量，而不影响IL-1α、IL-1β或肿瘤坏死因子α的产生，而罗红霉素则无此作用。据我们所知，这是首次证明一种抗生素能够增加IL-6的产生。
