Ziegler D K, Hur Y M, Bouchard T J, Hassanein R S, Barter R
Department of Neurology, University of Kansas Medical Center, Kansas City 66160-7314, USA.
Headache. 1998 Jun;38(6):417-22. doi: 10.1046/j.1526-4610.1998.3806417.x.
History of headache and migraine diagnosed by structured interview utilizing International Headache Society criteria was obtained in two samples of female twin pairs--154 raised together and 43 raised apart since infancy. Zygosity was determined by standard methods. Probandwise concordance rates were determined. Assuming that liability to migraine has a multifactorial etiology involving a number of genetic and environmental risk factors acting additively, tetrachoric correlations in the four groups of twins (monozygotic raised together, monozygotic raised apart, dizygotic raised together, and dizygotic raised apart) were then calculated. The genetic and environmental influences in the liability to migraine were estimated using biometrical model-fitting methods. Tetrachoric correlations of migraine were consistently higher in monozygotic than in dizygotic twins, for both reared together and reared apart samples, with a heritability estimate of 52%, Model fitting also suggested that approximately 50% of the variance in liability to migraine was attributable to genetic factors with nonshared environmental factors and measurement errors responsible for the remaining variance.
通过采用国际头痛协会标准的结构化访谈获取了头痛和偏头痛病史，该访谈针对两组女性双胞胎样本进行——154对自幼一起抚养长大的双胞胎以及43对自幼分开抚养长大的双胞胎。通过标准方法确定了双胞胎的同卵或异卵关系。计算了先证者一致率。假设偏头痛易感性具有多因素病因，涉及多个遗传和环境风险因素的累加作用，然后计算了四组双胞胎（一起抚养长大的同卵双胞胎、分开抚养长大的同卵双胞胎、一起抚养长大的异卵双胞胎以及分开抚养长大的异卵双胞胎）之间的四分相关系数。使用生物统计学模型拟合方法估计了偏头痛易感性中的遗传和环境影响。对于一起抚养和分开抚养的样本，同卵双胞胎中偏头痛的四分相关系数始终高于异卵双胞胎，遗传度估计为52%。模型拟合还表明，偏头痛易感性中约50%的变异可归因于遗传因素，其余变异则由非共享环境因素和测量误差导致。
