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基于核磁共振的蛋白质动力学

Protein dynamics from NMR.

作者信息

Kay L E

机构信息

Protein Engineering Network Centers of Excellence and the Department of Medical Genetics, University of Toronto, Ontario, Canada.

出版信息

Nat Struct Biol. 1998 Jul;5 Suppl:513-7. doi: 10.1038/755.

Abstract

In the past several years a significant number of new multidimensional NMR methods have been developed to study molecular dynamics spanning a wide range of time scales. Applications involving a large number of biological systems have emerged and correlations with function established. Unique insights are obtained that are not available from structure alone, indicating the importance of dynamics studies for understanding function.

摘要

在过去几年里,人们开发了大量新的多维核磁共振方法,用于研究跨越广泛时间尺度的分子动力学。涉及大量生物系统的应用已经出现,并建立了与功能的相关性。获得了仅从结构中无法获得的独特见解,这表明动力学研究对于理解功能的重要性。

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