Czermak B J, Lentsch A B, Bless N M, Schmal H, Friedl H P, Ward P A
Department of Trauma Surgery, University of Freiburg, Germany.
J Leukoc Biol. 1998 Jul;64(1):40-8. doi: 10.1002/jlb.64.1.40.
Complement is one of the integral buttresses of the inflammatory response. In addition to host defense activities, proinflammatory properties of several complement components are described. This overview elucidates the role of complement in inflammatory reactions in vitro and in vivo, focusing on the complement activation products, C5a, and the membrane attack complex, C5b-9. Using several approaches, the impact of these complement components in mechanisms relevant to neutrophil recruitment is emphasized. In addition, the participation of complement in endothelial superoxide generation and its essential requirement for full expression of lung injury is demonstrated, as are the involved intracellular signal transduction pathways. Understanding the mechanisms of complement-induced proinflammatory effects may provide a basis for future therapeutic blockade of complement and/or its activation products.
补体是炎症反应不可或缺的支撑要素之一。除了具有宿主防御活性外，几种补体成分还具有促炎特性。本综述阐述了补体在体外和体内炎症反应中的作用，重点关注补体激活产物C5a和膜攻击复合物C5b - 9。通过多种方法，强调了这些补体成分在与中性粒细胞募集相关机制中的作用。此外，还证明了补体参与内皮细胞超氧化物生成以及其对肺损伤充分表达的必要条件，以及所涉及的细胞内信号转导途径。了解补体诱导促炎作用的机制可能为未来对补体和/或其激活产物的治疗性阻断提供依据。
