Brown C G, Ilhan T, Kirvar E, Thomas M, Wilkie G, Leemans I, Hooshmand-Rad P
Centre for Tropical Veterinary Medicine, University of Edinburgh, Midlothian, Scotland, UK.
Ann N Y Acad Sci. 1998 Jun 29;849:44-51. doi: 10.1111/j.1749-6632.1998.tb11032.x.
Theileria annulata, causing bovine tropical theileriosis, and T. lestoquardi (syn T. hirci), the agent of malignant ovine theileriosis, are both transmitted by ticks of the genus Hyalomma. Their distribution is thus very similar and, should these parasites infect more than one ruminant species, the difficulty in interpreting epidemiological studies is magnified considerably. A pilot series of experiments was thus conducted in which cattle, sheep and goats were infected with sporozoites of a single stock of each of T. annulata and T. lestoquardi from a laboratory colony of H.a.anatolicum. Reciprocal cross-immunity and serological studies and in vitro culture isolations in mononuclear cells of each ruminant species illustrated both the similarity of these organisms and their differences. The importance of these findings in discriminating parasites in epidemiological studies and the control of these diseases with cell culture vaccines is emphasized.
环形泰勒虫可引发牛的热带泰勒虫病，而绵羊恶性泰勒虫（同物异名：山羊泰勒虫）是绵羊恶性泰勒虫病的病原体，二者均由璃眼蜱属蜱虫传播。因此，它们的分布非常相似，而且如果这些寄生虫感染不止一种反刍动物，那么解释流行病学研究结果的难度就会大大增加。因此开展了一系列初步实验，用来自安纳托利亚璃眼蜱实验室菌落的环形泰勒虫和绵羊恶性泰勒虫单一毒株的子孢子感染牛、绵羊和山羊。对每种反刍动物的单核细胞进行的交叉免疫和血清学研究以及体外培养分离，既显示了这些生物体的相似性，也显示了它们的差异。强调了这些发现在流行病学研究中鉴别寄生虫以及用细胞培养疫苗控制这些疾病方面的重要性。
