de Zubicaray G I, Williams S C, Wilson S J, Rose S E, Brammer M J, Bullmore E T, Simmons A, Chalk J B, Semple J, Brown A P, Smith G A, Ashton R, Doddrell D M
Neuroscience Research Programme, University of Queensland, Australia.
Cortex. 1998 Jun;34(3):389-401. doi: 10.1016/s0010-9452(08)70762-7.
Cerebral responses to alternating periods of a control task and a selective letter generation paradigm were investigated with functional Magnetic Resonance Imaging (fMRI). Subjects selectively generated letters from four designated sets of six letters from the English language alphabet, with the instruction that they were not to produce letters in alphabetical order either forward or backward, repeat or alternate letters. Performance during this condition was compared with that of a control condition in which subjects recited the same letters in alphabetical order. Analyses revealed significant and extensive foci of activation in a number of cerebral regions including mid-dorsolateral frontal cortex, inferior frontal gyrus, precuneus, supramarginal gyrus, and cerebellum during the selective letter generation condition. These findings are discussed with respect to recent positron emission tomography (PET) and fMRI studies of verbal working memory and encoding/retrieval in episodic memory.
利用功能磁共振成像（fMRI）研究了大脑对控制任务和选择性字母生成范式交替阶段的反应。受试者从英语字母表中四个指定的六个字母组中选择性地生成字母，并被指示不要按字母顺序向前或向后生成字母，不要重复或交替字母。将此条件下的表现与受试者按字母顺序背诵相同字母的控制条件下的表现进行比较。分析显示，在选择性字母生成条件下，包括背外侧额叶中部皮质、额下回、楔前叶、缘上回和小脑在内的多个脑区存在显著且广泛的激活灶。结合最近关于言语工作记忆以及情景记忆中编码/检索的正电子发射断层扫描（PET）和fMRI研究对这些发现进行了讨论。
