Brown S A, Phillips J, Ahsan G, Slater N G
Department of Haematology, Guy's & St Thomas' Hospital Trust, St Thomas' Hospital, London, UK.
Leuk Lymphoma. 1998 Jun;30(1-2):203-9. doi: 10.3109/10428199809050945.
Chronic lymphocytic leukaemia (CLL) and hairy cell leukaemia (HCL) are chronic B-cell lymphoproliferative disorders (B-LPDs) with distinct clinical, morphological and immunocytochemical features. Transformation of CLL into other B-LPDs (prolymphocytic leukaemia (PLL) and large cell lymphoma) is a well recognised phenomenon. One previous report has suggested that HCL may also arise by clonal evolution from CLL. We report the case of a 75 year old man in whom a diagnosis of coexisting HCL was made seventeen years after an initial diagnosis of CLL. Immunoglobulin heavy chain rearrangement studies suggest that the two B-LPDs developed independently. A steady increase in the bone marrow HCL component at the expense of the CLL component was observed with time, suggesting that HCL may have a growth advantage over CLL.
慢性淋巴细胞白血病（CLL）和毛细胞白血病（HCL）是慢性B淋巴细胞增殖性疾病（B-LPDs），具有不同的临床、形态学和免疫细胞化学特征。CLL转化为其他B-LPDs（幼淋巴细胞白血病（PLL）和大细胞淋巴瘤）是一种公认的现象。先前有一份报告提示，HCL也可能通过CLL的克隆进化产生。我们报告一例75岁男性患者，其在最初诊断为CLL十七年后又诊断出合并HCL。免疫球蛋白重链重排研究提示这两种B-LPDs是独立发生的。随着时间推移，观察到骨髓中HCL成分稳步增加，而CLL成分减少，提示HCL可能比CLL具有生长优势。
