Kirschner M, Gerhart J
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8420-7. doi: 10.1073/pnas.95.15.8420.
Evolvability is an organism's capacity to generate heritable phenotypic variation. Metazoan evolution is marked by great morphological and physiological diversification, although the core genetic, cell biological, and developmental processes are largely conserved. Metazoan diversification has entailed the evolution of various regulatory processes controlling the time, place, and conditions of use of the conserved core processes. These regulatory processes, and certain of the core processes, have special properties relevant to evolutionary change. The properties of versatile protein elements, weak linkage, compartmentation, redundancy, and exploratory behavior reduce the interdependence of components and confer robustness and flexibility on processes during embryonic development and in adult physiology. They also confer evolvability on the organism by reducing constraints on change and allowing the accumulation of nonlethal variation. Evolvability may have been generally selected in the course of selection for robust, flexible processes suitable for complex development and physiology and specifically selected in lineages undergoing repeated radiations.
可进化性是生物体产生可遗传表型变异的能力。后生动物的进化以巨大的形态和生理多样性为特征,尽管核心的遗传、细胞生物学和发育过程在很大程度上是保守的。后生动物的多样化需要进化出各种调控过程,以控制保守核心过程的使用时间、地点和条件。这些调控过程以及某些核心过程具有与进化变化相关的特殊属性。通用蛋白质元件、弱连接、区室化、冗余和探索行为等属性降低了组件之间的相互依赖性,并在胚胎发育和成年生理过程中赋予过程稳健性和灵活性。它们还通过减少对变化的限制并允许非致死性变异的积累,赋予生物体可进化性。在选择适合复杂发育和生理的稳健、灵活过程中,可进化性可能通常被选择,而在经历反复辐射的谱系中则被专门选择。