结核病中的异质性抗体反应。
Heterogeneous antibody responses in tuberculosis.
作者信息
Lyashchenko K, Colangeli R, Houde M, Al Jahdali H, Menzies D, Gennaro M L
机构信息
Public Health Research Institute, New York, New York 10016, USA.
出版信息
Infect Immun. 1998 Aug;66(8):3936-40. doi: 10.1128/IAI.66.8.3936-3940.1998.
Abstract
Antibody responses during tuberculosis were analyzed by an enzyme-linked immunosorbent assay with a panel of 10 protein antigens of Mycobacterium tuberculosis. It was shown that serum immunoglobulin G antibodies were produced against a variety of M. tuberculosis antigens and that the vast majority of sera from tuberculosis patients contained antibodies against one or more M. tuberculosis antigens. The number and the species of serologically reactive antigens varied greatly from individual to individual. In a given serum, the level of specific antibodies also varied with the antigen irrespective of the total number of antigens recognized by that particular serum. These findings indicate that person-to-person heterogeneity of antigen recognition, rather than recognition of particular antigens, is a key attribute of the antibody response in tuberculosis.
摘要
采用酶联免疫吸附测定法，利用一组10种结核分枝杆菌蛋白抗原，对结核病患者的抗体反应进行了分析。结果显示，血清免疫球蛋白G抗体针对多种结核分枝杆菌抗原产生，并且绝大多数结核病患者血清中含有针对一种或多种结核分枝杆菌抗原的抗体。血清学反应性抗原的数量和种类在个体之间差异很大。在给定的血清中，特异性抗体水平也因抗原而异，与该特定血清识别的抗原总数无关。这些发现表明，抗原识别的个体间异质性而非对特定抗原的识别，是结核病抗体反应的关键属性。
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本文引用的文献
1
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J Chromatogr B Biomed Sci Appl. 1998 Sep 4;714(2):223-35. doi: 10.1016/s0378-4347(98)00094-2.
2
MTC28, a novel 28-kilodalton proline-rich secreted antigen specific for the Mycobacterium tuberculosis complex.MTC28，一种针对结核分枝杆菌复合群的新型富含脯氨酸的28千道尔顿分泌抗原。
Infect Immun. 1997 Dec;65(12):4951-7. doi: 10.1128/iai.65.12.4951-4957.1997.
3
Molecular cloning, purification, and serological characterization of MPT63, a novel antigen secreted by Mycobacterium tuberculosis.结核分枝杆菌分泌的一种新型抗原MPT63的分子克隆、纯化及血清学特性分析
Infect Immun. 1997 Jan;65(1):16-23. doi: 10.1128/iai.65.1.16-23.1997.
4
Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis.结核分枝杆菌对异烟肼敏感性所需的过氧化氢酶-过氧化物酶编码基因katG的特征分析。
J Bacteriol. 1993 Jul;175(13):4255-9. doi: 10.1128/jb.175.13.4255-4259.1993.
5
Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis.结核分枝杆菌分泌的低分子量T细胞抗原的纯化与特性分析
Infect Immun. 1995 May;63(5):1710-7. doi: 10.1128/iai.63.5.1710-1717.1995.
6
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Scand J Immunol. 1995 May;41(5):433-42. doi: 10.1111/j.1365-3083.1995.tb03589.x.
7
The protective immune response to Mycobacterium tuberculosis.对结核分枝杆菌的保护性免疫反应。
Curr Opin Immunol. 1995 Aug;7(4):512-6. doi: 10.1016/0952-7915(95)80096-4.
8
The immune spectrum in patients with pulmonary tuberculosis.肺结核患者的免疫谱
Am Rev Respir Dis. 1981 May;123(5):556-9. doi: 10.1164/arrd.1981.123.5.556.
9
Antibody and antigen detection for the immunodiagnosis of tuberculosis: why not? What more is needed? Where do we stand today?
J Infect Dis. 1988 Oct;158(4):678-80. doi: 10.1093/infdis/158.4.678.
10
Immunodiagnostic assays for tuberculosis and leprosy.结核病和麻风病的免疫诊断检测
Br Med Bull. 1988 Jul;44(3):635-49. doi: 10.1093/oxfordjournals.bmb.a072273.
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