Fisher R, Saunders W B, Murray S J, Stave G M
Glaxo Wellcome, Inc., Research Triangle Park, NC 27709, USA.
J Occup Environ Med. 1998 Jul;40(7):609-13. doi: 10.1097/00043764-199807000-00005.
Laboratory animal allergy (LAA) is a significant occupational hazard for workers in a number of research settings, including the pharmaceutical industry. Prevention of allergy and asthma is important because the illness can affect health and career. In a major pharmaceutical company, in an effort to prevent LAA, a comprehensive program to reduce exposure to environmental allergens was developed. The program included education, engineering controls, administrative controls, use of personal protective equipment, and medical surveillance. A prospective survey of five years of data was completed to determine the effect of the program on the prevalence and incidence of LAA. After instituting this program, we found that the prevalence of LAA ranged from 12%-22% and that the incidence was reduced to zero during the last two years of observation. We concluded that LAA is preventable through the implementation of a comprehensive effort to reduce exposure to allergens.
实验动物过敏（LAA）对包括制药行业在内的许多研究环境中的工作人员来说是一项重大职业危害。预防过敏和哮喘很重要，因为这种疾病会影响健康和职业。在一家大型制药公司，为预防实验动物过敏，制定了一项减少接触环境过敏原的综合计划。该计划包括教育、工程控制、行政控制、使用个人防护设备以及医疗监测。完成了一项对五年数据的前瞻性调查，以确定该计划对实验动物过敏的患病率和发病率的影响。实施该计划后，我们发现实验动物过敏的患病率在12%至22%之间，并且在观察的最后两年发病率降至零。我们得出结论，通过实施减少接触过敏原的综合措施，实验动物过敏是可以预防的。
