Zacharisen M C, Kadambi A R, Schlueter D P, Kurup V P, Shack J B, Fox J L, Anderson H A, Fink J N
Department of Medicine, Medical College of Wisconsin, Milwaukee, USA.
J Occup Environ Med. 1998 Jul;40(7):640-7. doi: 10.1097/00043764-199807000-00010.
Occupational respiratory diseases have been reported following exposure to metal working fluids. We report a spectrum of respiratory illnesses occurring in an outbreak in 30 workers of an automobile parts engine manufacturing plant. Workers presented with respiratory complaints and, after clinical and laboratory evaluations, were classified as those having hypersensitivity pneumonitis, occupational asthma, or industrial bronchitis, or those without occupational lung disease. Hypersensitivity pneumonitis affected seven workers, with six exhibiting serum precipitins to Acinetobacter Iwoffii. Occupational asthma and industrial bronchitis affected 12 and six workers, respectively. Oil-mist exposures were below current recommendations. Gram-negative bacteria, but no fungi, Thermophiles, or Legionella, were identified. Although specific agents responsible for each individual case could not be identified, probably both specific sensitizing agents and non-specific irritants from metal working fluids, additives, or contaminants contributed to this spectrum of occupational respiratory illness.
接触金属加工液后已报告出现职业性呼吸系统疾病。我们报告了一家汽车零部件发动机制造工厂的30名工人中爆发的一系列呼吸系统疾病。工人们出现了呼吸道症状，经过临床和实验室评估后，被分类为患有过敏性肺炎、职业性哮喘或工业性支气管炎的工人，以及没有职业性肺病的工人。过敏性肺炎影响了7名工人，其中6名工人的血清对沃氏不动杆菌有沉淀素。职业性哮喘和工业性支气管炎分别影响了12名和6名工人。油雾暴露低于当前建议水平。鉴定出革兰氏阴性菌，但未发现真菌、嗜热菌或军团菌。尽管无法确定每个病例的具体致病因子，但金属加工液、添加剂或污染物中的特定致敏剂和非特异性刺激物可能都导致了这一系列职业性呼吸系统疾病。
