Scacchi R, De Bernardini L, Mantuano E, Vilardo T, Donini L M, Ruggeri M, Gemma A T, Pascone R, Corbo R M
CNR Center of Evolutionary Genetics, Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy.
Dement Geriatr Cogn Disord. 1998 Jul-Aug;9(4):186-90. doi: 10.1159/000017045.
The distribution of three DNA polymorphisms (XbaI, EcoRI, and I/D) of the apolipoprotein B (APOB) gene, and of the I/D polymorphism of the angiotensin I-converting enzyme (ACE) gene was investigated in 53 patients with vascular dementia, in 80 patients with late-onset sporadic Alzheimer's disease, and in 153 age-matched control subjects. Furthermore, plasma total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides were measured in the three groups and the involvement of the genetic variation at APOB locus on lipid levels was determined. Major findings of this work are (1) no genotype or allele of the polymorphisms examined here seemed to be associated with vascular dementia or with Alzheimer's disease, (2) total cholesterol and LDL cholesterol levels were lower in Alzheimer's disease patients than in vascular dementia patients and in elderly controls, and (3) the dementia patients with APOB EcoRI R+R- genotype had higher total cholesterol and LDL cholesterol levels than R+R+ homozygotes.
在53例血管性痴呆患者、80例晚发性散发性阿尔茨海默病患者以及153例年龄匹配的对照者中，研究了载脂蛋白B（APOB）基因的三种DNA多态性（XbaI、EcoRI和I/D）以及血管紧张素I转换酶（ACE）基因的I/D多态性的分布情况。此外，测定了三组人群的血浆总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯水平，并确定了APOB基因座的基因变异对血脂水平的影响。这项研究的主要发现是：（1）本文所检测的多态性的基因型或等位基因似乎均与血管性痴呆或阿尔茨海默病无关；（2）阿尔茨海默病患者的总胆固醇和低密度脂蛋白胆固醇水平低于血管性痴呆患者和老年对照者；（3）具有APOB EcoRI R+R-基因型的痴呆患者的总胆固醇和低密度脂蛋白胆固醇水平高于R+R+纯合子。
