Kreil T R, Burger I, Attakpah E, Olas K, Eibl M M
IMMUNO AG, Vienna, Austria.
Vaccine. 1998 May-Jun;16(9-10):955-9. doi: 10.1016/s0264-410x(97)00304-6.
Concomitant administration of an antigen and antibodies of the respective specificity has been shown to result in reduced levels of actively produced antibodies. This has also recently been observed in a clinical trial on simultaneous passive and active immunization against tick-borne encephalitis virus (TBEV). In the current study the influence of simultaneous passive and active immunization on vaccine induced protective immunity against TBEV has been evaluated in a mouse model. Two immunizations with licensed whole-killed TBEV vaccines gave close to complete protection. Administration of human or mouse TBEV antibodies together with the first vaccine dose resulted in a significant reduction of vaccine induced protection against TBEV challenge. This effect was even more pronounced than that observed earlier on the levels of vaccine induced antibody.
已证明同时给予抗原和具有相应特异性的抗体可导致主动产生的抗体水平降低。最近在一项针对蜱传脑炎病毒（TBEV）的同时进行被动和主动免疫的临床试验中也观察到了这一点。在当前研究中，已在小鼠模型中评估了同时进行被动和主动免疫对疫苗诱导的针对TBEV的保护性免疫的影响。用许可的全灭活TBEV疫苗进行两次免疫可提供近乎完全的保护。将人或小鼠TBEV抗体与第一剂疫苗一起给予会导致疫苗诱导的针对TBEV攻击的保护作用显著降低。这种效应比早期在疫苗诱导的抗体水平上观察到的效应更为明显。
