Roche H M, Zampelas A, Jackson K G, Williams C M, Gibney M J
Unit of Nutrition, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Ireland.
Br J Nutr. 1998 May;79(5):419-24. doi: 10.1079/bjn19980071.
Epidemiological evidence shows that a diet high in monounsaturated fatty acids (MUFA) but low in saturated fatty acids (SFA) is associated with reduced risk of CHD. The hypocholesterolaemic effect of MUFA is known but there has been little research on the effect of test meal MUFA and SFA composition on postprandial lipid metabolism. The present study investigated the effect of meals containing different proportions of MUFA and SFA on postprandial triacylglycerol and non-esterified fatty acid (NEFA) metabolism. Thirty healthy male volunteers consumed three meals containing equal amounts of fat (40 g), but different proportions of MUFA (12, 17 and 24% energy) in random order. Postprandial plasma triacylglycerol, apolipoprotein B-48, cholesterol, HDL-cholesterol, glucose and insulin concentrations and lipoprotein lipase (EC 3.1.1.34) activity were not significantly different following the three meals which varied in their levels of SFA and MUFA. There was a significant difference in the postprandial NEFA response between meals. The incremental area under the curve of postprandial plasma NEFA concentrations was significantly (P = 0.03) lower following the high-MUFA meal. Regression analysis showed that the non-significant difference in fasting NEFA concentrations was the most important factor determining difference between meals, and that the test meal MUFA content had only a minor effect. In conclusion, varying the levels of MUFA and SFA in test meals has little or no effect on postprandial lipid metabolism.
流行病学证据表明，富含单不饱和脂肪酸（MUFA）但饱和脂肪酸（SFA）含量低的饮食与冠心病风险降低有关。MUFA的降胆固醇作用是已知的，但关于试验餐中MUFA和SFA组成对餐后脂质代谢影响的研究很少。本研究调查了含有不同比例MUFA和SFA的餐食对餐后三酰甘油和非酯化脂肪酸（NEFA）代谢的影响。30名健康男性志愿者随机食用三餐，三餐脂肪含量相等（40克），但MUFA比例不同（能量的12%、17%和24%）。在三种SFA和MUFA水平不同的餐后，餐后血浆三酰甘油、载脂蛋白B-48、胆固醇、高密度脂蛋白胆固醇、葡萄糖和胰岛素浓度以及脂蛋白脂肪酶（EC 3.1.1.34）活性无显著差异。餐食之间餐后NEFA反应存在显著差异。高MUFA餐餐后血浆NEFA浓度曲线下增量面积显著更低（P = 0.03）。回归分析表明，空腹NEFA浓度的无显著差异是决定餐食间差异的最重要因素，而试验餐MUFA含量影响较小。总之，改变试验餐中MUFA和SFA的水平对餐后脂质代谢几乎没有影响。
