Zampelas A, Roche H, Knapper J M, Jackson K G, Tornaritis M, Hatzis C, Gibney M J, Kafatos A, Gould B J, Wright J, Williams C M
School of Biological Sciences, University of Surrey, Guildford, UK.
Atherosclerosis. 1998 Jul;139(1):83-93. doi: 10.1016/s0021-9150(98)00061-6.
Postprandial lipaemic responses to two test meals were investigated in 30 Northern (15 British and 15 Irish), and 30 Southern (Greeks from Crete) healthy male Europeans. The meals were a saturated fatty acid (SFA) meal, which resembled the fatty acid composition of an average UK diet, and a monounsaturated fatty acid (MUFA) meal in which the fat consisted of olive oil. Habitual diets of the two groups differed, with higher total fat, (P < 0.03) and MUFA (P < 0.0001) and lower polyunsaturated fatty acid (PUFA) (P < 0.0001) intakes in Southern than Northern Europeans. Levels of total MUFA (P < 0.02) and oleic acid (P < 0.004) were also higher in adipose tissue of Southern in comparison to Northern Europeans. In both European groups there were no significant differences in postprandial triglyceride response between the two meal types, SFA or MUFA. However, Northern and Southern Europeans showed significant differences in their patterns of postprandial response in plasma triglycerides (P < 0.0001), apolipoprotein B-48 (P < 0.0001), NEFA (P < 0.0001), insulin (P < 0.0007), and factor VII activity (P-0.03). In the case of NEFA, areas under the response curve were higher following the SFA than the MUFA meal for both groups, (P < 0.003) and were greater in Southern than Northern Europeans (P < 0.002) and apo B-48 responses were lower (P < 0.005). Some of these differences may reflect differences in fasting levels since fasting apolipoprotein B-48 levels were lower (P < 0.01) and fasting NEFA (P < 0.02) and insulin (P < 0.005) were higher in the Southern than in the Northern Europeans. In addition, 9 h postprandial post-heparin lipoprotein lipase activity was lower in the Southern than in the Northern Europeans (P < 0.0006). This is the first report of differences in postprandial lipid, factor VII and insulin responses in Southern and Northern Europeans which may be of importance in explaining the different susceptibilities of these two populations to risk of coronary artery disease.
对30名北欧（15名英国人和15名爱尔兰人）和30名南欧（来自克里特岛的希腊人）健康男性欧洲人进行了研究，以调查他们对两种测试餐的餐后血脂反应。这两种餐分别是饱和脂肪酸（SFA）餐，其脂肪酸组成类似于英国平均饮食；以及单不饱和脂肪酸（MUFA）餐，其脂肪由橄榄油组成。两组的习惯性饮食有所不同，南欧人的总脂肪摄入量（P < 0.03）、MUFA摄入量（P < 0.0001）较高，而多不饱和脂肪酸（PUFA）摄入量（P < 0.0001）较低。与北欧人相比，南欧人脂肪组织中的总MUFA水平（P < 0.02）和油酸水平（P < 0.004）也更高。在两个欧洲组中，两种餐类型（SFA或MUFA）之间的餐后甘油三酯反应均无显著差异。然而，北欧人和南欧人在血浆甘油三酯（P < 0.0001）、载脂蛋白B - 48（P < 0.0001）、非酯化脂肪酸（NEFA）（P < 0.0001）、胰岛素（P < 0.0007）和凝血因子VII活性（P - 0.03）的餐后反应模式上存在显著差异。就NEFA而言，两组在SFA餐后的反应曲线下面积均高于MUFA餐（P < 0.003），且南欧人高于北欧人（P < 0.002），而载脂蛋白B - 48反应较低（P < 0.005）。其中一些差异可能反映了空腹水平的差异，因为南欧人的空腹载脂蛋白B - 48水平较低（P < 0.01），而空腹NEFA（P < 0.02）和胰岛素（P < 0.005）水平高于北欧人。此外，餐后9小时肝素后脂蛋白脂肪酶活性在南欧人低于北欧人（P < 0.0006）。这是关于北欧人和南欧人餐后脂质、凝血因子VII和胰岛素反应差异的首次报告，这可能对解释这两个人群对冠状动脉疾病风险的不同易感性具有重要意义。
