Leonhardt A, Dahlen G
Department of Oral Microbiology, Faculty of Obdontology, Goeteborg University, Sweden.
Eur J Oral Sci. 1995 Dec;103(6):382-7. doi: 10.1111/j.1600-0722.1995.tb01861.x.
Titanium granules were tested for their antibacterial effect on strains of Streptococcus sanguis, Streptococcus mitis, Actinomyces naeslundii, Haemophilus parainfluenzae, Fusobacterium spp. and Prevotella intermedia in comparison with amalgam and two of its components, copper and tin. Glass beads were used as controls. The number of viable bacteria was estimated in samples exposed to the various materials for 1, 3, 6 and 24 h, respectively, and the viable counts were related to the baseline value. Titanium showed low antibacterial effect on the species tested. Copper and amalgam showed an expressed toxicity to all species and differed significantly from titanium and glass particles. Gram positive Streptococcus spp. and A. naeslundii showed a lower susceptibility to the metals than the Gram negative species. The antibacterial effect of copper and amalgam test particles on S. sanguis and P. intermedia was significantly decreased in the presence of serum. This study showed that some metals have a toxic effect in vitro on oral bacteria, a fact that may play a role in plaque formation when these materials are used for dental restorations. Titanium did not have a similar antibacterial effect.
将钛颗粒与汞合金及其两种成分铜和锡相比，测试了其对血链球菌、缓症链球菌、内氏放线菌、副流感嗜血杆菌、梭杆菌属和中间普氏菌菌株的抗菌效果。玻璃珠用作对照。分别估计暴露于各种材料1、3、6和24小时的样品中的活菌数量，活菌计数与基线值相关。钛对测试的菌种显示出较低的抗菌效果。铜和汞合金对所有菌种均表现出明显的毒性，与钛和玻璃颗粒有显著差异。革兰氏阳性链球菌属和内氏放线菌对金属的敏感性低于革兰氏阴性菌种。在血清存在的情况下，铜和汞合金测试颗粒对血链球菌和中间普氏菌的抗菌效果显著降低。本研究表明，一些金属在体外对口腔细菌有毒性作用，当这些材料用于牙齿修复时，这一事实可能在菌斑形成中起作用。钛没有类似的抗菌效果。
