Radfar Lida, Shea Yvonne, Fischer Steven H, Sankar Vidya, Leakan Rose Anne, Baum Bruce J, Pillemer Stanley R
State Univeristy of New York, Buffalo, NY 14214, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Sep;96(3):283-7. doi: 10.1016/s1079-2104(03)00224-5.
We sought to investigate the prevalence of Candida carriage and the relationships between salivary flow rates and oral Candida load in patients with Sjögren's syndrome (SS).
The oral Candida load of patients with SS was evaluated by culturing oral rinse (swish and spit) samples. Culture, Gram stain, and wet-mount test results were reported.
One hundred three patients (96 women) met European criteria for SS (91 with primary SS and 12 with secondary SS). The mean age (95% confidence interval) was 55 years (range, 51-57 years). Oral rinse cultures were positive in 77% of subjects. The total stimulated salivary flow rate was inversely correlated with oral Candida load (r = -0.47; P </=.0001). The oral rinse samples yielded gram-positive results in 38% of patients with SS, and the Fungi-Fluor assay (wet mount) results were positive in 49%.
The prevalence of Candida carriage varies according to the methods used to determine the presence of the organism and is similar to that reported in the literature. A low stimulated salivary flow rate-not a low unstimulated flow rate-was associated with Candida carriage.
我们试图调查干燥综合征（SS）患者念珠菌携带情况以及唾液流速与口腔念珠菌负荷之间的关系。
通过培养口腔含漱（漱口水并吐出）样本评估SS患者的口腔念珠菌负荷。报告培养、革兰氏染色和湿片检查结果。
103例患者（96例女性）符合欧洲SS诊断标准（91例原发性SS，12例继发性SS）。平均年龄（95%置信区间）为55岁（范围51 - 57岁）。77%的受试者口腔含漱培养呈阳性。总刺激唾液流速与口腔念珠菌负荷呈负相关（r = -0.47；P≤0.0001）。SS患者中38%的口腔含漱样本革兰氏染色结果为阳性，49%的真菌荧光检测（湿片）结果为阳性。
念珠菌携带率因确定该微生物存在的方法而异，与文献报道相似。刺激唾液流速低而非非刺激流速低与念珠菌携带有关。
