Rasmussen F, Johansson M
Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Eur J Epidemiol. 1998 Jun;14(4):373-80. doi: 10.1023/a:1007411613576.
The intrauterine environment seems to be important for the occurrence of cardiovascular and other chronic diseases in adulthood. The aim of the present study is to analyze the importance of birthweight, birthlength and Ponderal Index (PI) for Body Mass Index (BMI) and overweight at 18 years of age. In this cohort study, the nationwide Swedish Medical Birth Registry for the years 1973-1976 was linked with the national Military Service Conscription Registry for 1990-1996. Of 193,056 children born at term 1973-1976, 165,109 (85.5%) could be followed-up at 18 years of age. The children were divided into percentile groups according to birthweight and birthlength for each gestational week. They were also assigned to three different categories, according to birthweight and birthlength for each gestational week: infants with values < or = 5th percentile, values > 5th and < or = 95th percentile, and values > 95th percentile. Clear-cut associations were found between birthweight and BMI, and between PI at birth and BMI at 18 years of age. High birthweight and normal birthlength and also high birthweight and high birthlength for gestational age were found to be risk factors for overweight and severe overweight among young men in Sweden.
子宫内环境似乎对成年后心血管疾病和其他慢性疾病的发生具有重要意义。本研究的目的是分析出生体重、出生身长和体重指数（PI）对18岁时体重指数（BMI）和超重情况的重要性。在这项队列研究中，将1973 - 1976年瑞典全国性的医学出生登记册与1990 - 1996年的国家兵役征兵登记册相链接。在1973 - 1976年足月出生的193,056名儿童中，165,109名（85.5%）在18岁时能够被随访。根据每个孕周的出生体重和出生身长，将儿童分为百分位数组。他们还根据每个孕周的出生体重和出生身长被分为三个不同类别：值≤第5百分位数的婴儿、值＞第5百分位数且≤第95百分位数的婴儿以及值＞第95百分位数的婴儿。研究发现出生体重与BMI之间、出生时的PI与18岁时的BMI之间存在明确的关联。在瑞典年轻男性中，高出生体重和正常出生身长以及高出生体重和相对于孕周的高出生身长被发现是超重和重度超重的危险因素。
