Tzanakis N, Bouros D, Samiou M, Panagou P, Mouzas J, Manousos O, Siafakas N
Department of Thoracic Medicine, Medical School University of Crete, Greece.
Respir Med. 1998 Mar;92(3):516-22. doi: 10.1016/s0954-6111(98)90301-8.
Previous studies on baseline pulmonary function testing (PFT) abnormalities in patients with inflammatory bowel disease (IBD) are conflicting because most of them have incorporated patients suffering from both ulcerative colitis (UC) and Crohn's disease (CD). The aim of the study is to investigate whether any PFT abnormalities could be detected in a large group of IBD patients and whether there are differences between the two IBD entities. A total of 132 patients, 47 with CD (mean age 35 years) and 85 with UC (mean age 40 years) were studied. Pulmonary function tests (PFTs), lung transfer factor for carbon monoxide (TLCO) were examined and compared with those of 36 healthy controls. No significant difference of mean values of spirometric indices, TLCO and ABG was found between the two groups of patients and controls, or between patients with CD and UC. However, nine (19%) patients with CD and 15 (17.6%) with UC had a reduction in TLCO, a percentage significantly higher than in controls (P < 0.05). The majority of the patients with TLCO reduction were in an active phase of disease (P < 0.05). Our results suggest that there is no difference in routine PFTs between UC and CD patients, as well as between both these groups and normal controls. However, TLCO abnormalities related to the degree of disease activity are found in patients with both UC and CD.
以往关于炎症性肠病（IBD）患者基线肺功能测试（PFT）异常的研究结果相互矛盾，因为大多数研究纳入了溃疡性结肠炎（UC）和克罗恩病（CD）患者。本研究旨在调查在一大群IBD患者中是否能检测到任何PFT异常，以及这两种IBD实体之间是否存在差异。共研究了132例患者，其中47例为CD患者（平均年龄35岁），85例为UC患者（平均年龄40岁）。进行了肺功能测试（PFT），检测了一氧化碳肺弥散量（TLCO），并与36名健康对照者的结果进行比较。两组患者与对照者之间，以及CD患者与UC患者之间，在肺量计指标、TLCO和动脉血气（ABG）的平均值上均未发现显著差异。然而，9例（19%）CD患者和15例（17.6%）UC患者的TLCO降低，这一比例显著高于对照组（P<0.05）。大多数TLCO降低的患者处于疾病活动期（P<0.05）。我们的结果表明，UC患者和CD患者之间，以及这两组患者与正常对照者之间，常规PFT没有差异。然而，在UC和CD患者中均发现与疾病活动程度相关的TLCO异常。
