Jeansonne M J, White R R
Dental Branch, University of Texas Health Science Center, Houston.
J Endod. 1994 Jun;20(6):276-8. doi: 10.1016/s0099-2399(06)80815-0.
Sodium hypochlorite, as an endodontic irrigant, poses problems including toxicity, odor, and discoloration of operatory items. An equally effective, but safer irrigant is desirable. Therefore, we compared the antimicrobial activity of 2.0% chlorhexidine gluconate with that of 5.25% sodium hypochlorite in an in vitro root canal system. Freshly extracted human teeth with pulpal pathosis were instrumented using chlorhexidine, sodium hypochlorite, or saline as irrigants. Microbiological samples were taken from the teeth immediately after accessing the canal, after instrumentation and irrigation, and after standing in an anaerobic atmosphere for 24 h. Irrigation with chlorhexidine or sodium hypochlorite significantly reduced the numbers of postirrigant positive cultures and colony-forming units compared with saline-irrigated teeth. The number of postirrigant positive cultures and the number of colony-forming units in positive cultures obtained from chlorhexidine-treated teeth were lower than the numbers obtained from sodium hypochlorite-treated teeth, but the differences were not statistically significant.
次氯酸钠作为一种根管冲洗剂，存在诸如毒性、气味以及使手术器械变色等问题。因此，需要一种同样有效但更安全的冲洗剂。所以，我们在体外根管系统中比较了2.0%葡萄糖酸氯己定和5.25%次氯酸钠的抗菌活性。将患有牙髓病变的新鲜拔除的人牙，分别使用氯己定、次氯酸钠或生理盐水作为冲洗剂进行根管预备。在开髓后、根管预备和冲洗后以及在厌氧环境中放置24小时后，立即从牙齿采集微生物样本。与用生理盐水冲洗的牙齿相比，用氯己定或次氯酸钠冲洗显著减少了冲洗后阳性培养物的数量和菌落形成单位。从氯己定处理的牙齿获得的冲洗后阳性培养物数量和阳性培养物中的菌落形成单位数量低于从次氯酸钠处理的牙齿获得的数量，但差异无统计学意义。
