Derbyshire S W, Jones A K
PET Facility, University of Pittsburgh Medical Center, PA 15213, USA.
Pain. 1998 May;76(1-2):127-35. doi: 10.1016/s0304-3959(98)00034-7.
We have previously demonstrated the localised positron emission tomographic cerebral correlates of the experience of painful phasic heat in the normal human brain. In this study we examine whether these responses are different using a continuous, tonic heat stimulus. The regional cerebral responses to non-painful and painful thermal stimuli in 12 male subjects were studied by monitoring serial measurements of regional cerebral blood flow (rCBF) with positron emission tomography (PET) using H2(15)O. Significantly increased rCBF responses to tonic noxious stimulation compared with non-noxious stimulation were observed bilaterally in the anterior cingulate (Brodmann's area (BA) 24) cortex. Contralateral responses were observed in the lentiform nucleus and posterior insula cortex and ipsilateral responses were observed in the thalamus, cerebellum, prefrontal (BA 10) cortex and anterior insula cortex. These findings demonstrate general agreement between the main areas of cerebral activation during both phasic and tonic pain.
我们之前已经证明了正常人类大脑中痛性相位热觉体验的局部正电子发射断层扫描脑关联。在本研究中，我们使用持续的、紧张性热刺激来检查这些反应是否不同。通过使用H2(15)O的正电子发射断层扫描（PET）监测局部脑血流（rCBF）的系列测量，研究了12名男性受试者对非痛性和痛性热刺激的局部脑反应。与非伤害性刺激相比，在双侧前扣带回（布罗德曼区（BA）24）皮质观察到对紧张性伤害性刺激的rCBF反应显著增加。在豆状核和后岛叶皮质观察到对侧反应，在丘脑、小脑、前额叶（BA 10）皮质和前岛叶皮质观察到同侧反应。这些发现表明，在相位性和紧张性疼痛期间，大脑激活的主要区域之间存在总体一致性。
