Lammers W J, Stephen B, Adeghate E, Ponery S, Pozzan O
Department of Physiology, UAE University, Al Ain, United Arab Emirates.
Neurogastroenterol Motil. 1998 Aug;10(4):339-49. doi: 10.1046/j.1365-2982.1998.00113.x.
Detailed spatial analysis of the propagation of individual slow waves was performed in the isolated gastroduodenal preparation of the cat. Use was made of a system that allowed the simultaneous recordings from 240 extracellular electrodes, which were positioned across the gastroduodenal region. Reconstructions of the spread of propagation (n = 31) revealed that (a) the antral slow wave never propagated into the duodenum but was blocked at the pyloric ring, (b) the duodenal slow wave did not activate the antral tissue, and (c) a quiescent zone in which no slow waves could be recorded was always present at the most proximal part of the duodenum immediately distal to the pyloric ring. Furthermore, phase density distributions of duodenal cycles revealed that antral activity had no influence on the rate of discharge of duodenal pacemakers. Light microscopic study of sections of the duodenum close to the pyloric ring and further away did not show any structural differences between the quiescent zone and the active areas. In conclusion, slow waves do not propagate across the gastroduodenal junction in the isolated feline preparation and therefore do not seem to play a role in the electro-mechanical integration between the stomach and the duodenum.
在猫的离体胃十二指肠标本中，对单个慢波的传播进行了详细的空间分析。使用了一个系统，该系统允许从横跨胃十二指肠区域放置的240个细胞外电极同时进行记录。对传播扩散的重建（n = 31）显示：（a）胃窦慢波从未传播到十二指肠，而是在幽门环处受阻；（b）十二指肠慢波未激活胃窦组织；（c）在紧邻幽门环远端的十二指肠最近端部分，始终存在一个无法记录到慢波的静止区。此外，十二指肠周期的相位密度分布表明，胃窦活动对十二指肠起搏器的放电频率没有影响。对靠近幽门环及更远部位的十二指肠切片进行的光学显微镜研究未显示静止区与活跃区之间存在任何结构差异。总之，在离体猫标本中，慢波不会跨越胃十二指肠交界处传播，因此似乎在胃与十二指肠之间的电机械整合中不起作用。
