González M E, Francis L, Castellano O
Neurobiochemistry Laboratory, International Center for Neurological Restoration, Playa Ciudad de la Habana, Cuba.
J Neural Transm Suppl. 1998;53:333-41. doi: 10.1007/978-3-7091-6467-9_29.
Levels of catalase (CAT) and superoxide dismutase (SOD) activity were determinate in serum of intact rats (INT) and those with septohippocampal pathway lesion (SHPL), which received Cerebrolysin (CRB) or saline solution (SAL) for a week. We found that Cerebrolysin induces a decrease on the CAT and SOD levels. Decrease of CAT levels (19.1) in the group of SHPL-CRB was higher than the values obtained (57.3) in SHPL-SAL group. The lowest CAT levels were detected in the INT-CER group (16.7). The SOD levels obtained in SHPL-CER group (9.84) were also smaller than those obtained in the SHPL-SAL group (14.9) which showed the highest levels of SOD, while the INT animals showed the lowest levels (7.6). In addition, the SHPL animals mortality was of 18% for the CER group against 43% for SAL group. We suggest the Cerebrolysin effect on CAT and SOD activity is related with a beneficial antioxidative role which may have potential application on brain injury.
在完整大鼠（INT）以及海马隔区通路损伤大鼠（SHPL）的血清中测定过氧化氢酶（CAT）和超氧化物歧化酶（SOD）的活性水平，这些大鼠接受了脑蛋白水解物（CRB）或生理盐水（SAL）治疗一周。我们发现脑蛋白水解物会导致CAT和SOD水平降低。SHPL - CRB组中CAT水平的降低（19.1）高于SHPL - SAL组所获得的值（57.3）。在INT - CER组中检测到最低的CAT水平（16.7）。SHPL - CER组中获得的SOD水平（9.84）也低于SHPL - SAL组（14.9），SHPL - SAL组显示出最高的SOD水平，而INT组动物的SOD水平最低（7.6）。此外，CER组的SHPL动物死亡率为18%，而SAL组为43%。我们认为脑蛋白水解物对CAT和SOD活性的影响与有益的抗氧化作用有关，这可能在脑损伤方面具有潜在应用价值。
