Fukunaga M, Ushigome S
The Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.
Pathol Int. 1998 Jul;48(7):562-5. doi: 10.1111/j.1440-1827.1998.tb03950.x.
A case of uterine bizarre lipoleiomyoma occurring in a 58-year-old woman is described. A subserosal 8.5 cm mass in the posterior wall of the body had a lipoma-like appearance with strands of fibrous tissue. Histologically, the tumor predominantly consisted of adipocytes which varied in size and shape. Some cells had the appearance of signet ring cells, some had hyperchromatic nuclei, and multivacuolated lipoblasts with hyperchromatic nuclei were observed throughout the lesion. The fibrous areas showed a proliferation of smooth muscle cells with and without atypical nuclei. There was no mitotic figure. Flow cytometric analysis indicated aneuploidy. The patient was well without disease 10 months after hysterectomy. Patients with this type of tumor need a close and long-term follow-up because of the paucity of clinical information.
本文描述了一例发生在一名58岁女性身上的子宫奇异型脂肪平滑肌瘤。子宫体后壁浆膜下有一个8.5厘米的肿块，外观呈脂肪瘤样，伴有纤维组织条索。组织学上，肿瘤主要由大小和形状各异的脂肪细胞组成。一些细胞呈印戒样外观，一些细胞核染色质增多，在整个病变区域均观察到多核空泡状脂肪母细胞且细胞核染色质增多。纤维区域显示有平滑肌细胞增生，部分细胞核有异型性，未见核分裂象。流式细胞术分析显示为非整倍体。患者子宫切除术后10个月情况良好，无疾病复发。由于此类肿瘤的临床资料较少，患有这种类型肿瘤的患者需要密切且长期的随访。
