Mizugaki Y, Sugawara Y, Shinozaki F, Takada K
Department of Oral and Maxillofacial Surgery, Yamaguchi University School of Medicine, Kogushi, Ube.
Jpn J Cancer Res. 1998 Jun;89(6):604-7. doi: 10.1111/j.1349-7006.1998.tb03261.x.
Fifty-one cases of malignant and non-malignant oral diseases were investigated for Epstein-Barr virus (EBV). EBV DNA was detected by polymerase chain reaction analysis in 2 of 4 papillomas, but not in other tissues including 36 squamous cell carcinomas and 4 leukoplakias. The copy numbers of EBV DNA in the two positive samples were estimated to be 120 and 36 per cell, respectively. Intense EBV DNA signals were detected on papilloma cells by in situ hybridization. DNAs for the benign and malignant types of human papilloma virus were not detected in papilloma tissues. The present results suggest that EBV is a causative agent of oral papilloma.
对51例恶性和非恶性口腔疾病患者进行了爱泼斯坦-巴尔病毒（EBV）检测。通过聚合酶链反应分析，在4例乳头状瘤中有2例检测到EBV DNA，而在包括36例鳞状细胞癌和4例白斑在内的其他组织中未检测到。两个阳性样本中EBV DNA的拷贝数估计分别为每个细胞120和36。通过原位杂交在乳头状瘤细胞上检测到强烈的EBV DNA信号。在乳头状瘤组织中未检测到人类乳头瘤病毒良性和恶性类型的DNA。目前的结果表明EBV是口腔乳头状瘤的病原体。
