Floyd S, De Camilli P
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.
Trends Cell Biol. 1998 Aug;8(8):299-301. doi: 10.1016/s0962-8924(98)01316-6.
Recent studies have shown that a variety of proteins participate with clathrin and clathrin adaptors in receptor-mediated endocytosis. The genes encoding some of these proteins are targets of chromosomal rearrangements in human haematopoietic malignancies. In addition, abnormal expression or mutation of some endocytosis proteins has been reported in human cancers. This article discusses these observations and elaborates the potential mechanisms by which the abnormal expression of endocytosis proteins might participate in the biology of cancer.
最近的研究表明，多种蛋白质与网格蛋白及网格蛋白衔接蛋白一起参与受体介导的内吞作用。编码其中一些蛋白质的基因是人类造血系统恶性肿瘤中染色体重排的靶点。此外，在人类癌症中也报道了一些内吞作用蛋白的异常表达或突变。本文讨论了这些观察结果，并阐述了内吞作用蛋白异常表达可能参与癌症生物学过程的潜在机制。
