Freiburghaus F, Steck A, Pfander H, Brun R
University of Berne, Department of Chemistry and Biochemistry, Switzerland.
J Ethnopharmacol. 1998 Jul;61(3):179-83. doi: 10.1016/s0378-8741(98)00035-x.
Bioassay-guided fractionation of the dichloromethane rootbark extract of Entada abyssinica (Leguminosae), a plant used by traditional healers in Uganda for the treatment of sleeping sickness, led to the isolation of a diastereoisomer of the clerodane type diterpene kolavenol. This is the first report on this compound. It showed a trypanocidal activity with an IC50 value of 2.5 microg/ml (8.6 microM) against Trypanosoma brucei rhodesiense, the causing agent of the acute form of human African trypanosomiasis.
对乌干达传统治疗师用于治疗昏睡病的植物阿比西尼亚榼藤子（豆科）二氯甲烷根皮提取物进行生物测定导向的分级分离，得到了克罗烷型二萜可乐韦醇的非对映异构体。这是关于该化合物的首次报道。它对布氏罗得西亚锥虫（人类非洲锥虫病急性形式的致病因子）显示出杀锥虫活性，IC50值为2.5微克/毫升（8.6微摩尔）。
