Muro J, Ramis A, Pastor J, Velarde R, Tarres J, Lavin S
Clínica Veterinaria Prat de la Creu, Principality of Andorra, Spain.
J Wildl Dis. 1998 Jul;34(3):487-95. doi: 10.7589/0090-3558-34.3.487.
An epidemic of chronic rhinitis in a population of 50 captive spur-thighed tortoises (Testudo graeca graeca) from Palafrugell (Girona, Spain) is described, in which eight animals died and 12 were euthanatized to perform necropsies and post-mortem studies. The main clinical sign was a bilateral, seromucous rhinitis often accompanied by stomatitis and glossitis. Hematology and serum biochemistry were performed in 33 of the 50 ill animals and in 29 healthy tortoises from three disease-free populations. Lymphocyte count, aspartate aminotransferase (AST) activity, and alpha-globulin levels were significantly higher in the animals from the sick population. The heterophil count was significantly lower in the sick animals. Some of the diseased tortoises also showed a normocytic-normochromic anemia. Lesions were restricted to the respiratory system and oral cavity. Marked epithelial hyperplasia and presence of a severe mixed inflammatory infiltrate in the epithelium of the oral, nasal, and tracheal mucosae were observed. Electron microscopy demonstrated the presence of intracytoplasmic and intranuclear viral particles of the size, shape, and distribution pattern typical of a herpesvirus.
本文描述了西班牙赫罗纳省帕拉菲鲁杰尔的50只圈养希腊陆龟（Testudo graeca graeca）群体中发生的慢性鼻炎疫情，其中8只动物死亡，12只被安乐死以进行尸检和死后研究。主要临床症状为双侧浆液性鼻炎，常伴有口腔炎和舌炎。对50只患病动物中的33只以及来自三个无病群体的29只健康陆龟进行了血液学和血清生化检测。患病群体动物的淋巴细胞计数、天冬氨酸转氨酶（AST）活性和α-球蛋白水平显著更高。患病动物的嗜异性粒细胞计数显著更低。一些患病陆龟还表现为正细胞正色素性贫血。病变局限于呼吸系统和口腔。观察到口腔、鼻腔和气管黏膜上皮明显增生，上皮内有严重的混合性炎性浸润。电子显微镜显示存在大小、形状和分布模式典型的疱疹病毒的胞质内和核内病毒颗粒。
