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胃黏膜相关淋巴组织（MALT）低度B细胞淋巴瘤生发中心滤泡树突状细胞上幽门螺杆菌相关抗原和热休克蛋白60的检测

Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT).

作者信息

Kobayashi K, Yokota K, Yoshino T, Kawahara Y, Dey A, Hirai Y, Oguma K, Akagi T

机构信息

Department of Pathology, Okayama University Medical School, Japan.

出版信息

J Clin Pathol. 1998 May;51(5):396-8. doi: 10.1136/jcp.51.5.396.

DOI:10.1136/jcp.51.5.396
PMID:9708209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC500703/
Abstract

AIMS

To investigate the localisation of Helicobacter pylori antigens and the expression of human heat shock proteins (HSP) in stomachs affected by MALT lymphoma.

METHODS

Surgically resected stomachs from 24 patients with MALT lymphoma were immunostained with anti-H pylori rabbit antibodies (ORP-1 and ORP-2) and anti-human HSP60 mouse monoclonal antibodies (mAb) (LK-1 and LK-2).

RESULTS

Follicular dendritic cells of germinal centres in the stomachs affected by MALT lymphoma were immunostained with anti-H pylori polyclonal antibodies and with anti-human HSP60 mAb, as were the epithelial cells. None of the lymph node samples reacted.

CONCLUSIONS

Human HSP60, which cross reacts with anti-H pylori polyclonal antibodies, is often expressed on follicular dendritic cells in gastric MALT lymphoma tissues and may be aetiologically relevant to lymphomagenesis of MALT lymphoma.

摘要

目的

研究幽门螺杆菌抗原的定位以及人热休克蛋白（HSP）在胃黏膜相关淋巴组织（MALT）淋巴瘤累及胃中的表达情况。

方法

用抗幽门螺杆菌兔抗体（ORP - 1和ORP - 2）以及抗人HSP60小鼠单克隆抗体（mAb）（LK - 1和LK - 2）对24例MALT淋巴瘤患者手术切除的胃组织进行免疫染色。

结果

MALT淋巴瘤累及胃的生发中心滤泡树突状细胞以及上皮细胞用抗幽门螺杆菌多克隆抗体和抗人HSP60 mAb免疫染色均呈阳性。所有淋巴结样本均无反应。

结论

与人抗幽门螺杆菌多克隆抗体发生交叉反应的人HSP60常在胃MALT淋巴瘤组织的滤泡树突状细胞上表达，可能与MALT淋巴瘤的淋巴瘤发生在病因学上相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a0/500703/5a417a560f42/jclinpath00266-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a0/500703/1ca8ff6f5f34/jclinpath00266-0052-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a0/500703/5a417a560f42/jclinpath00266-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a0/500703/1ca8ff6f5f34/jclinpath00266-0052-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a0/500703/5a417a560f42/jclinpath00266-0053-a.jpg

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Detection of immunoglobulin heavy chain gene rearrangement by polymerase chain reaction in chronic active gastritis associated with Helicobacter pylori.
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