Singh R B, Niaz M A, Ghosh S, Beegom R, Agarwal P, Nangia S, Moshiri M, Janus E D
Heart Research Laboratory, Medical Hospital and Research Center, Moradabad, India.
J Am Coll Nutr. 1998 Aug;17(4):342-50. doi: 10.1080/07315724.1998.10718773.
To determine the association between saturated fat intake and prevalence of coronary artery disease (CAD) and coronary risk factors.
Total community cross sectional survey of 20 urban streets out of 196 streets, in the city of Moradabad in north India.
Adult population between 25 to 64 years inclusive comprised of 1806 subjects (904 men, 902 women) were divided into three groups according to level of saturated fat intake as assessed by 7-day dietary intake records (very low < 7%, low 7 to 10%, high > 10% energy (en) per day).
We examined the relationship between CAD risk and levels of % en from fat intake. Low (7 to 10% en/day) and high (> 10% en/day) saturated fat were positively and significantly associated with higher prevalence of CAD. The prevalence of coronary risk factors (hypertension, hypercholesterolemia, obesity and sedentary lifestyle) were significantly higher among subjects with low and high saturated fat intake compared to subjects with very low (< 7%) saturated fat intake. Logistic regression analysis with adjustment for age showed that hypercholesterolemia (OR: men 0.89, women 0.68), hypertension (men 0.92, women 0.56), physical activity (men 0.80, women 0.36), obesity (men 0.82, women 0.88) and smoking (0.70 men) were significant risk factors of CAD. Low and high saturated fat intake were associated with more prestigious occupations, higher and middle income status and better educational levels compared to very low saturated fat intake.
The prevalence of CAD and coronary risk factors was higher in urban Indians with low and high saturated fat intake than those with lower saturated fat intake. These findings suggest that the saturated fat intake should be < 7% en/day for prevention of CAD in Indians.
确定饱和脂肪摄入量与冠状动脉疾病（CAD）患病率及冠状动脉危险因素之间的关联。
对印度北部莫拉达巴德市196条街道中的20条城市街道进行全社区横断面调查。
根据7天饮食摄入记录评估的饱和脂肪摄入量水平，将年龄在25至64岁（含）之间的1806名成年人（904名男性，902名女性）分为三组（极低<7%、低7至10%、高>10%每日能量（en））。
我们研究了CAD风险与脂肪摄入能量百分比水平之间的关系。低（7至10%en/天）和高（>10%en/天）饱和脂肪与CAD较高患病率呈正相关且具有显著相关性。与饱和脂肪摄入量极低（<7%）的受试者相比，饱和脂肪摄入量低和高的受试者中冠状动脉危险因素（高血压、高胆固醇血症、肥胖和久坐不动的生活方式）的患病率显著更高。经年龄调整的逻辑回归分析表明，高胆固醇血症（比值比：男性0.89，女性0.68）、高血压（男性0.92，女性0.56）、身体活动（男性0.80，女性0.36）、肥胖（男性0.82，女性0.88）和吸烟（男性0.70）是CAD的显著危险因素。与饱和脂肪摄入量极低相比，低和高饱和脂肪摄入量与更有声望的职业、中高收入地位和更好的教育水平相关。
饱和脂肪摄入量低和高的城市印度人CAD及冠状动脉危险因素的患病率高于饱和脂肪摄入量较低的人。这些发现表明，为预防印度人的CAD，饱和脂肪摄入量应<7%en/天。
