Guilfoyle T J, Ulmasov T, Hagen G
Department of Biochemistry, University of Missouri, Columbia 65211, USA.
Cell Mol Life Sci. 1998 Jul;54(7):619-27. doi: 10.1007/s000180050190.
Auxin response factors or ARFs are a recently discovered family of transcription factors that bind with specificity to auxin response elements (AuxREs) in promoters of primary or early auxin-responsive genes. ARFs have an amino-terminal DNA-binding domain related to the carboxyl-terminal DNA-binding domain in the maize transactivator VIVIPAROUS1. All but one ARF identified to date contain a carboxyl-terminal protein-protein interaction domain that forms a putative amphipathic alpha-helix. A similar carboxyl-terminal protein-protein interaction domain is found in the Aux/IAA class of auxin-inducible proteins. Some ARFs contain transcriptional activation domains, while others contain repression domains. ARFs appear to play a pivotal role in auxin-regulated gene expression of primary response genes.
生长素响应因子（ARFs）是最近发现的一类转录因子，它们能特异性地结合到初级或早期生长素响应基因启动子中的生长素响应元件（AuxREs）上。ARFs具有一个与玉米反式激活因子VIVIPAROUS1中的羧基末端DNA结合结构域相关的氨基末端DNA结合结构域。迄今为止鉴定出的所有ARFs（只有一个除外）都含有一个羧基末端蛋白质-蛋白质相互作用结构域，该结构域形成一个假定的两亲性α螺旋。在生长素诱导蛋白的Aux/IAA类中也发现了类似的羧基末端蛋白质-蛋白质相互作用结构域。一些ARFs含有转录激活结构域，而另一些则含有抑制结构域。ARFs似乎在生长素调节的初级反应基因的基因表达中起关键作用。
