Ota H, Katsuyama T, Nakajima S, El-Zimaity H, Kim J G, Graham D Y, Genta R M
Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA.
Hum Pathol. 1998 Aug;29(8):846-50. doi: 10.1016/s0046-8177(98)90455-5.
Helicobacter pylori seem to avoid areas of intestinal metaplasia in the gastric mucosa, but attachment of these bacteria to epithelium with the appearance of incomplete intestinal metaplasia has been documented. To characterize the nature of the epithelium to which H pylori was attached, we carried out an immunohistochemical study using monoclonal antibodies against gastric surface mucous cell mucins (M1), blood group-related carbohydrates antigens (Le(a), sialyl Le(a), Le(b), type 1H, and type 2H) and sialyl Tn antigen. The results of this study suggest that these areas of H pylori attachment represent a hybrid epithelium whose cells share characteristics of both gastric surface mucous cells and intestinal metaplastic cells. Whether all areas of incomplete intestinal metaplasia represent an intermediate stage between the normal gastric epithelium and the fully developed complete type of metaplasia remains to be determined.
幽门螺杆菌似乎会避开胃黏膜中的肠化生区域，但这些细菌附着于具有不完全肠化生外观的上皮细胞的情况已有记录。为了表征幽门螺杆菌所附着的上皮细胞的性质，我们使用针对胃表面黏液细胞黏蛋白（M1）、血型相关碳水化合物抗原（Le(a)、唾液酸化Le(a)、Le(b)、1型H和2型H）以及唾液酸化Tn抗原的单克隆抗体进行了一项免疫组织化学研究。这项研究的结果表明，这些幽门螺杆菌附着区域代表一种混合上皮，其细胞兼具胃表面黏液细胞和肠化生细胞的特征。所有不完全肠化生区域是否代表正常胃上皮与完全发育的完全型化生之间的中间阶段仍有待确定。
