重组表面抗原1与白细胞介素-12联合疫苗接种对小鼠弓形虫病的保护作用
Protective effect of vaccination with a combination of recombinant surface antigen 1 and interleukin-12 against toxoplasmosis in mice.
作者信息
Letscher-Bru V, Villard O, Risse B, Zauke M, Klein J P, Kien T T
机构信息
Institut de Parasitologie et de Pathologie Tropicale, Inserm U392, Faculté de Médecine, 67000 Strasbourg, France.
出版信息
Infect Immun. 1998 Sep;66(9):4503-6. doi: 10.1128/IAI.66.9.4503-4506.1998.
Abstract
We studied the immune response induced in mice by recombinant Toxoplasma gondii surface antigen 1 (rSAG1) protein, alone or combined with interleukin-12 (IL-12) as an adjuvant, and the protective effect against toxoplasmosis. Immunization with rSAG1 alone induced a specific humoral type 2 immunity and did not protect the animals from infection. In contrast, immunization with rSAG1 plus IL-12 redirected humoral and cellular immunity toward a type 1 pattern and reduced the brain parasite load by 40%.
摘要
我们研究了重组弓形虫表面抗原1（rSAG1）蛋白单独或与白细胞介素-12（IL-12）作为佐剂联合使用时在小鼠体内诱导的免疫反应，以及对弓形虫病的保护作用。单独用rSAG1免疫诱导了特异性体液2型免疫，但不能保护动物免受感染。相比之下，用rSAG1加IL-12免疫可使体液和细胞免疫转向1型模式，并使脑内寄生虫负荷降低40%。
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