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Experimental enteric colibacillosis in piglets.仔猪实验性肠道大肠杆菌病
Can J Comp Med. 1968 Jul;32(3):493-7.
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Non-O157 Shiga toxin-producing Escherichia coli infections in Europe.欧洲非O157产志贺毒素大肠杆菌感染
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Emerging foodborne diseases.新出现的食源性疾病。
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Pathogenicity of Escherichia coli O157:H7 in the intestines of neonatal calves.大肠杆菌O157:H7在新生犊牛肠道中的致病性。
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Activation of Shiga-like toxins by mouse and human intestinal mucus correlates with virulence of enterohemorrhagic Escherichia coli O91:H21 isolates in orally infected, streptomycin-treated mice.小鼠和人肠道黏液对志贺样毒素的激活与肠出血性大肠杆菌O91:H21分离株在经链霉素处理的口服感染小鼠中的毒力相关。
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The role of the eae gene of enterohemorrhagic Escherichia coli in intimate attachment in vitro and in a porcine model.肠出血性大肠杆菌的eae基因在体外和猪模型中紧密黏附中的作用。
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Profile of Escherichia coli O157:H7 pathogen responsible for hamburger-borne outbreak of hemorrhagic colitis and hemolytic uremic syndrome in Washington.
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Animals as a source of Escherichia coli pathogenic for human beings.作为对人类致病的大肠杆菌来源的动物。
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Enterohemorrhagic Escherichia coli O157:H7 requires intimin to colonize the gnotobiotic pig intestine and to adhere to HEp-2 cells.肠出血性大肠杆菌O157:H7需要紧密黏附素才能在无菌猪肠道中定殖并黏附于HEp-2细胞。
Infect Immun. 1995 Sep;63(9):3739-44. doi: 10.1128/iai.63.9.3739-3744.1995.
10
Outbreak of acute gastroenteritis attributable to Escherichia coli serotype O104:H21--Helena, Montana, 1994.1994年，蒙大拿州海伦娜市由大肠杆菌O104:H21血清型引起的急性肠胃炎暴发。
MMWR Morb Mortal Wkly Rep. 1995 Jul 14;44(27):501-3.

大肠杆菌O157:H7在犊牛中引发肠道致病性需要紧密黏附素。

Escherichia coli O157:H7 requires intimin for enteropathogenicity in calves.

作者信息

Dean-Nystrom E A, Bosworth B T, Moon H W, O'Brien A D

机构信息

Enteric Diseases and Food Safety Research Unit, National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa 50010, USA.

出版信息

Infect Immun. 1998 Sep;66(9):4560-3. doi: 10.1128/IAI.66.9.4560-4563.1998.

DOI:10.1128/IAI.66.9.4560-4563.1998
PMID:9712821
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC108559/
Abstract

Enterohemorrhagic Escherichia coli (EHEC) strains require intimin to induce attaching and effacing (A/E) lesions in newborn piglets. Infection of newborn calves with intimin-positive or intimin-negative EHEC O157:H7 demonstrated that intimin is needed for colonization, A/E lesions, and disease in cattle. These results suggest that experiments to determine if intimin-based vaccines reduce O157:H7 levels in cattle are warranted.

摘要

肠出血性大肠杆菌（EHEC）菌株需要紧密黏附素才能在新生仔猪中诱导黏附和损毁（A/E）性损伤。用紧密黏附素阳性或阴性的EHEC O157:H7感染新生牛犊表明，紧密黏附素是牛体内定植、A/E损伤和发病所必需的。这些结果表明，有必要进行实验来确定基于紧密黏附素的疫苗是否能降低牛体内O157:H7的水平。