关于鸽主动脉微粒体和上清液部分中的胆固醇酯水解酶活性
On the cholesteryl ester hydrolase activity in the microsomal and supernatant fractions of pigeon aorta.
作者信息
Subbiah M T, Dicke B A
出版信息
Atherosclerosis. 1976 Sep;24(3):575-80. doi: 10.1016/0021-9150(76)90149-0.
Cholesteryl ester hydrolase activity was measured in the microsomal and supernatant fractions of the aorta of atherosclerosis-susceptible White Carneau and atherosclerosis-resistant Show Racer pigeons while on their normal cholesterol-free diets. Enzyme activities from both fractions showed fatty acid specificities for the hydrolysis of different cholesteryl esters in the following decreasing order: Linoleate greater than oleate greater than palmitate. At 9 months of age (the period of lipid accumulation) the microsomal enzyme activity in the Show Racer breed was significantly higher (P less than 0.001) than in the White Carneau breed, while the supernatant enzyme was slightly higher (P less than 0.05) in the White Carneaux at this age. In older birds (3 years of age) these differences in enzyme activities disappeared.
在易患动脉粥样硬化的白卡诺鸽和抗动脉粥样硬化的赛鸽正常食用无胆固醇饮食时，测量了其主动脉微粒体和上清液部分的胆固醇酯水解酶活性。两个部分的酶活性对不同胆固醇酯水解的脂肪酸特异性表现为以下递减顺序：亚油酸酯＞油酸酯＞棕榈酸酯。在9个月大时（脂质积累期），赛鸽品种的微粒体酶活性显著高于白卡诺鸽品种（P＜0.001），而在这个年龄，白卡诺鸽的上清液酶活性略高（P＜0.05）。在年长的鸟类（3岁）中，这些酶活性差异消失了。
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