前列腺素E1和F1α对体外培养的鸽主动脉胆固醇酯合成酶及胆固醇酯水解酶活性的影响。
Effect of prostaglandins E1 and F1alpha on the activities of cholesteryl ester synthetase and cholesteryl ester hydrolases of pigeon aorta in vitro.
作者信息
Subbiah M T, Dicke B A
出版信息
Atherosclerosis. 1977 May;27(1):107-11. doi: 10.1016/0021-9150(77)90030-2.
The in vitro effects of prostaglandins E1 and F1alpha on the activity of cholesteryl ester synthetase and cholesteryl ester hydrolase activities of the pigeon aorta were examined. It was found that prostaglandin E1 markedly inhibited the cholesteryl ester hydrolase activity in the supernatant fraction and slightly inhibited the cholesteryl ester synthetase activity. Prostaglandin F1alpha, however, modestly stimulated the cholesteryl ester hydrolase activity both in the microsomal and in the supernatant fraction of the aorta. These observations strongly warrant further studies on the role of prostaglandins in atherogenesis.
研究了前列腺素E1和F1α对鸽主动脉胆固醇酯合成酶活性及胆固醇酯水解酶活性的体外作用。结果发现，前列腺素E1显著抑制上清液部分的胆固醇酯水解酶活性，并轻微抑制胆固醇酯合成酶活性。然而，前列腺素F1α适度刺激主动脉微粒体和上清液部分的胆固醇酯水解酶活性。这些观察结果有力地证明有必要进一步研究前列腺素在动脉粥样硬化形成中的作用。
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