Pastor J C
Instituto Universitario de Oftalmobiología Aplicada (IOBA), University of Valladolid, Spain.
Surv Ophthalmol. 1998 Jul-Aug;43(1):3-18. doi: 10.1016/s0039-6257(98)00023-x.
Proliferative vitreoretinopathy (PVR) is still the most common cause of failure of surgery for rhegmatogenous retinal detachment, despite the substantial effort that has been devoted to better understanding and managing this condition during the past 25 years. Basic research has indicated that PVR represents scarring, the end stage of the wound-healing process that occurs after retinal detachment surgery. Medical treatment has been directed toward preventing inflammation, the first phase of the wound healing process, and inhibiting cell proliferation, the second phase. The 1983 Retina Society classification was modified in 1989 by the Silicone Study Group, whose classification differentiates between posterior and anterior forms of PVR and recognizes three patterns of proliferation: diffuse, focal, and subretinal. The anterior form has a worse prognosis than the posterior form, and its treatment requires more complex surgical procedures. In this review, risk factors and pathobiology of PVR are discussed, and management of PVR of various degrees of severity are considered.
增殖性玻璃体视网膜病变（PVR）仍然是孔源性视网膜脱离手术失败最常见的原因，尽管在过去25年里人们付出了巨大努力来更好地理解和处理这种疾病。基础研究表明，PVR代表瘢痕形成，是视网膜脱离手术后伤口愈合过程的终末期。医学治疗一直致力于预防炎症（伤口愈合过程的第一阶段）和抑制细胞增殖（第二阶段）。1983年视网膜协会的分类在1989年被硅胶研究组修改，该组的分类区分了PVR的后部和前部形式，并识别出三种增殖模式：弥漫性、局灶性和视网膜下。前部形式的预后比后部形式更差，其治疗需要更复杂的手术程序。在这篇综述中，讨论了PVR的危险因素和病理生物学，并考虑了不同严重程度PVR的处理方法。
