Jansen G J, Wildeboer-Veloo A C, van der Waaij D, Degener J E
Laboratory of Medical Microbiology, University of Groningen, The Netherlands.
Infection. 1998 Jul-Aug;26(4):232-3. doi: 10.1007/BF02962369.
The influence of oral treatment with a suspension of non-pathogenic Escherichia coli cells (commercially available as: Symbioflor II) on the morphological composition of the gut microflora and on the systemic humoral immune response (the IgG-, IgA- and IgM-isotype) against the bacterial cells in the Symbioflor II preparation was measured. After a pretreatment period of 21 days, ten healthy human volunteers ingested 1*10(8) cells of E. coli daily for 14 days. Thereafter a follow-up period of 28 days completed the study. The results of this study indicated that no effect of the treatment on the composition of the gut microflora could be observed. However, the immune-fluorescence measurements revealed a significant increase in circulating amounts of IgG directed against the administered E. coli cells. It is concluded that the treatment only resulted in a specific humoral immune response, while the gut microflora is not modulated.
测定了口服非致病性大肠杆菌细胞悬液（商品名为：Symbioflor II）对肠道微生物群形态组成以及对Symbioflor II制剂中细菌细胞的全身性体液免疫反应（IgG、IgA和IgM同种型）的影响。在21天的预处理期后，10名健康人类志愿者连续14天每天摄入1×10⁸个大肠杆菌细胞。此后，28天的随访期完成了该研究。这项研究的结果表明，未观察到该治疗对肠道微生物群组成有影响。然而，免疫荧光测量显示，针对所施用大肠杆菌细胞的循环IgG量显著增加。得出的结论是，该治疗仅导致特异性体液免疫反应，而肠道微生物群未受到调节。
