Hanson K M, Simon J D
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0341, USA.
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10576-8. doi: 10.1073/pnas.95.18.10576.
The premature photoaging of the skin is mediated by the sensitization of reactive oxygen species after absorption of ultraviolet radiation by endogenous chromophores. Yet identification of UV-A-absorbing chromophores in the skin that quantitatively account for the action spectra of the physiological responses of photoaging has remained elusive. This paper reports that the in vitro action spectrum for singlet oxygen generation after excitation of trans-urocanic acid mimics the in vivo UV-A action spectrum for the photosagging of mouse skin. The data presented provide evidence suggesting that the UV-A excitation of trans-urocanic acid initiates chemical processes that result in the photoaging of skin.
皮肤的过早光老化是由内源性发色团吸收紫外线辐射后活性氧的敏化作用介导的。然而，在皮肤中鉴定出能够定量解释光老化生理反应作用光谱的紫外线A吸收发色团仍然难以实现。本文报道，反式尿刊酸激发后单线态氧生成的体外作用光谱模拟了小鼠皮肤光下垂的体内紫外线A作用光谱。所提供的数据表明，反式尿刊酸的紫外线A激发引发了导致皮肤光老化的化学过程。
