表皮反式尿刊酸与紫外线A诱导的皮肤光老化
Epidermal trans-urocanic acid and the UV-A-induced photoaging of the skin.
作者信息
Hanson K M, Simon J D
机构信息
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0341, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10576-8. doi: 10.1073/pnas.95.18.10576.
Abstract
The premature photoaging of the skin is mediated by the sensitization of reactive oxygen species after absorption of ultraviolet radiation by endogenous chromophores. Yet identification of UV-A-absorbing chromophores in the skin that quantitatively account for the action spectra of the physiological responses of photoaging has remained elusive. This paper reports that the in vitro action spectrum for singlet oxygen generation after excitation of trans-urocanic acid mimics the in vivo UV-A action spectrum for the photosagging of mouse skin. The data presented provide evidence suggesting that the UV-A excitation of trans-urocanic acid initiates chemical processes that result in the photoaging of skin.
摘要
皮肤的过早光老化是由内源性发色团吸收紫外线辐射后活性氧的敏化作用介导的。然而，在皮肤中鉴定出能够定量解释光老化生理反应作用光谱的紫外线A吸收发色团仍然难以实现。本文报道，反式尿刊酸激发后单线态氧生成的体外作用光谱模拟了小鼠皮肤光下垂的体内紫外线A作用光谱。所提供的数据表明，反式尿刊酸的紫外线A激发引发了导致皮肤光老化的化学过程。
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本文引用的文献
1
The origin of the wavelength-dependent photoreactivity of trans-urocanic acid.反式尿刊酸波长依赖性光反应性的起源。
Photochem Photobiol. 1998 May;67(5):538-40.
2
The effects of UVA-I (340-400 nm), UVA-II (320-340 nm) and UVA-I+II on the photoisomerization of urocanic acid in vivo.UVA-I（340 - 400纳米）、UVA-II（320 - 340纳米）以及UVA-I + II对体内尿刊酸光异构化的影响。
Photochem Photobiol. 1997 Oct;66(4):484-92. doi: 10.1111/j.1751-1097.1997.tb03177.x.
3
Singlet oxygen is an early intermediate in cytokine-dependent ultraviolet-A induction of interstitial collagenase in human dermal fibroblasts in vitro.单线态氧是体外培养的人皮肤成纤维细胞中细胞因子依赖性紫外线A诱导间质胶原酶产生过程中的早期中间体。
FEBS Lett. 1997 Aug 18;413(2):239-42. doi: 10.1016/s0014-5793(97)00919-8.
4
Singlet oxygen mediates the activation of JNK by UVA radiation in human skin fibroblasts.单线态氧介导紫外线A辐射对人皮肤成纤维细胞中JNK的激活作用。
FEBS Lett. 1997 May 26;408(3):289-91. doi: 10.1016/s0014-5793(97)00440-7.
5
The hairless mouse model for photoaging.光老化的无毛小鼠模型。
Clin Dermatol. 1996 Mar-Apr;14(2):183-95. doi: 10.1016/0738-081x(95)00154-8.
6
The effect of photodamage on dermal extracellular matrix.光损伤对真皮细胞外基质的影响。
Clin Dermatol. 1996 Mar-Apr;14(2):143-51. doi: 10.1016/0738-081x(95)00149-a.
7
Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene.转录因子AP-2的激活介导了紫外线A辐射和单线态氧诱导的人类细胞间黏附分子1基因的表达。
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14586-91. doi: 10.1073/pnas.93.25.14586.
8
Oxidative stress, caloric restriction, and aging.氧化应激、热量限制与衰老
Science. 1996 Jul 5;273(5271):59-63. doi: 10.1126/science.273.5271.59.
9
Antioxidant defense mechanisms in murine epidermis and dermis and their responses to ultraviolet light.小鼠表皮和真皮中的抗氧化防御机制及其对紫外线的反应。
J Invest Dermatol. 1993 Mar;100(3):260-5. doi: 10.1111/1523-1747.ep12469048.
10
Singlet oxygen induces collagenase expression in human skin fibroblasts.单线态氧可诱导人皮肤成纤维细胞中胶原酶的表达。
FEBS Lett. 1993 Oct 4;331(3):304-6. doi: 10.1016/0014-5793(93)80357-z.
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