Ghadirian P, Maisonneuve P, Perret C, Lacroix A, Boyle P
Research Center, CHUM, Department of Nutrition, University of Montreal, Quebec, Canada.
Cancer Detect Prev. 1998;22(5):396-404. doi: 10.1046/j.1525-1500.1998.00058.x.
Colon cancer is the second most common cancer in both men and women in North America and other developed countries. In a population-based case-control study of colon cancer among French Canadians in greater Montreal, a total of 402 cases and 668 controls were interviewed. The cancer cases were identified through the admission offices of five major Francophone teaching hospitals in Montreal from 1989 to 1993. The controls, matched by age, sex, place of residence, and language, were selected by a modified random digit dialing method. The results show that subjects who had ever been married had a lower risk for colon cancer (odds ratio [OR]: 0.58; 95% confidence interval [95% CI]: 0.48-0.84) than did individuals who had never been married. A significant association (OR: 1.90; p for trend = 0.003) was found between the height of subjects and the risk of colon cancer. The OR for individuals with a family history of colorectal cancer was 2.78 with a p value of 0.01. A direct and significant association (OR: 2.01) was found among constipation, use of laxatives (OR: 1.41), and the risk of colon cancer. Among women, a suggestive inverse association was detected between the number of full-term pregnancies and the risk of colon cancer in female subjects (the OR for five or more pregnancies was 0.58 with a p for trend of 0.08). There was also a suggestive linear trend (increased age-decreased risk) between age at menarche and the risk of colon cancer. No association was apparent between other sociodemographic characteristics and the risk of colon cancer. In conclusion, married individuals had lower risk for colon cancer, perhaps due to food habits or other characteristics of being single. Higher height and weight history 10 years before the diagnosis of cancer are risk factors for breast cancer, while both current weight and body mass index seem to be protective. Positive family history of colon cancer increased the risk of colon cancer significantly.
在北美和其他发达国家，结肠癌是男性和女性中第二常见的癌症。在一项针对大蒙特利尔地区法裔加拿大人的基于人群的结肠癌病例对照研究中，共采访了402例病例和668名对照。癌症病例是通过蒙特利尔五家主要法语教学医院的入院办公室在1989年至1993年期间确定的。对照通过改良的随机数字拨号方法选择，按年龄、性别、居住地点和语言进行匹配。结果显示，曾经结婚的受试者患结肠癌的风险（优势比[OR]：0.58；95%置信区间[95%CI]：0.48 - 0.84）低于从未结婚的个体。在受试者身高与结肠癌风险之间发现了显著关联（OR：1.90；趋势p值 = 0.003）。有结直肠癌家族史的个体的OR为2.78，p值为0.01。在便秘、使用泻药（OR：1.41）与结肠癌风险之间发现了直接且显著的关联（OR：2.01）。在女性中，检测到足月妊娠次数与女性受试者患结肠癌风险之间存在提示性的负相关（五次或更多次妊娠的OR为0.58，趋势p值为0.08）。初潮年龄与结肠癌风险之间也存在提示性的线性趋势（年龄增加风险降低）。其他社会人口统计学特征与结肠癌风险之间未发现明显关联。总之，已婚个体患结肠癌的风险较低，可能是由于饮食习惯或单身的其他特征。癌症诊断前10年较高的身高和体重史是乳腺癌的风险因素，而当前体重和体重指数似乎具有保护作用。结肠癌的阳性家族史显著增加了患结肠癌的风险。
