Peters R D, Hinks R S, Henkelman R M
Department of Medical Biophysics, University of Toronto, Sunnybrook Health Science Center, Ontario, Canada.
Magn Reson Med. 1998 Sep;40(3):454-9. doi: 10.1002/mrm.1910400316.
The temperature sensitivity of the proton-resonance frequency (PRF) has proven valuable for the monitoring of MR image-guided thermal coagulation therapy. However, there is significant inconsistency in reported values of the PRF-thermal coefficient, as measured from experiments encompassing a range of in vivo and ex vivo tissue types and experimental conditions. A method of calibrating the temperature dependence of the PRF is described and results are presented that indicate a tissue-type independence. To this end, other possible mechanisms for variations in the PRF-thermal coefficient are suggested, including physiological perturbations and volume magnetic susceptibility effects from geometry and orientation.
质子共振频率（PRF）的温度敏感性已被证明在监测磁共振成像引导的热凝固治疗中具有重要价值。然而，在一系列体内和体外组织类型以及实验条件下进行的实验所测得的PRF热系数报告值存在显著不一致。本文描述了一种校准PRF温度依赖性的方法，并给出了表明组织类型无关性的结果。为此，提出了PRF热系数变化的其他可能机制，包括生理扰动以及几何形状和方向引起的体积磁化率效应。
