Moss D M, Chappell C L, Okhuysen P C, DuPont H L, Arrowood M J, Hightower A W, Lammie P J
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30341, USA.
J Infect Dis. 1998 Sep;178(3):827-33. doi: 10.1086/515377.
Previous studies have suggested that persons infected with Cryptosporidium parvum develop antibody responses to 27-, 17-, and 15-kDa C. parvum antigens. Studies of volunteers infected with Cryptosporidium species provided an opportunity to evaluate the relationship between antibody reactivity to these antigens and infection outcome. As monitored by immunoblot, increases in specific antibody reactivity were more prevalent among volunteers who developed signs and symptoms of cryptosporidiosis (n = 11) than among asymptomatic infected (n = 7; P = .05) or oocyst-negative volunteers (n = 11; P = .02). Volunteers with preexisting IgG antibody to the 27-kDa antigen excreted fewer oocysts than volunteers without this antibody (P = .003). IgG reactivity to the 17-kDa antigens and IgM reactivity to the 27-kDa antigens were higher at day 0 for asymptomatic infected persons than for those who developed symptoms (P = .03 and P = .04, respectively). These results suggest that characteristic antibody responses develop following C. parvum infection and that persons with preexisting antibodies may be less likely to develop illness.
先前的研究表明，感染微小隐孢子虫的人会对27 kDa、17 kDa和15 kDa的微小隐孢子虫抗原产生抗体反应。对感染隐孢子虫属的志愿者进行的研究为评估对这些抗原的抗体反应性与感染结果之间的关系提供了机会。通过免疫印迹监测，在出现隐孢子虫病体征和症状的志愿者（n = 11）中，特异性抗体反应性增加的情况比无症状感染者（n = 7；P = 0.05）或卵囊阴性志愿者（n = 11；P = 0.02）中更为普遍。对27 kDa抗原预先存在IgG抗体的志愿者排出的卵囊比没有这种抗体的志愿者少（P = 0.003）。无症状感染者在第0天时对17 kDa抗原的IgG反应性和对27 kDa抗原的IgM反应性高于出现症状者（分别为P = 0.03和P = 0.04）。这些结果表明，微小隐孢子虫感染后会出现特征性的抗体反应，并且预先存在抗体的人患病的可能性可能较小。
